Effect of Initial Empirical PEEP Setting on the Esophageal Pressure-guided PEEP Titration in ARDS

Completed

• Conditions: PEEP, Occult; ARDS, Human; Esophageal and Pleural Pressure

• Registration Number: NCT05442073
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

Esophageal manometry was used as surrogate of pleural pressure to titrate positive end-expiratory pressure (PEEP) in ARDS patients. However, Absolute values of esophageal pressure (Pes) could be affected by the PEEP setting. In moderate to severe ARDS patients, the end-expiratory Pes changed differently with PEEP adjustment. and the esophageal phenotypes could be divided into type I and type II. with Type I （ΔPes≥30%ΔPEEP）and Type II（ΔPes\<30%ΔPEEP）.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-03-01
• Primary Completion: 2022-05-31
• Status Verified: 2022-06
• Study First Submitted: 2022-06-28
• Study First Submitted QC: 2022-06-28
• Last Update Submitted: 2022-06-28
• Study Completion: 2022-06-29
• Study First Posted: 2022-07-01
• Last Update Posted: 2022-07-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• aged over 18 all the moderate to severe ARDS patients invasive mechanical ventilation

Exclusion Criteria

• aged<18 contraindication to esophageal catheter

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the changes of esophageal pressure during the PEEP titration	March 1st to May 31st, 2022

Trial Locations

Locations (1)

Peking Union Medical College Hospital; 🇨🇳 Beijing, Beijing, China