Treatment of Chronic Renal Failure With Adipose Tissue-derived Mesenchymal Stem Cells

Not Applicable

• Conditions: Renal Interstitial Fibrosis; Mesenchymal Stem Cells; Chronic Kidney Diseases
• Interventions: Drug: Control group; Drug: Treatment group

• Registration Number: NCT03321942
• Lead Sponsor: The Affiliated Hospital of Xuzhou Medical University

Brief Summary

To investigate the biological characteristics of adipose tissue-derived mesenchymal stem cells(AMSCs) and its treatment effects on chronic renal failure.

Detailed Description

This study aims to investigate the biological characteristics of adipose tissue-derived mesenchymal stem cells(AMSCs) and its effect on oxidative stress, inflammation and mitochondrial damage.We intend to use blood oxygen level-dependent magnetic resonance imaging(BOLD-MRI), emission computed tomography(ECT) and enhanced magnetic resonance imaging to monitor renal oxygenation, tissue perfusion and renal function.Ultimately, we evaluate the treatment effects of AMSCs on chronic renal failure through these observations mentioned above.We hope to delay the progression of renal function in patients with chronic renal failure, and save huge social cost for dialysis by these research.

Study Timeline

• Study Start: 2017-01-01
• Status Verified: 2017-10
• Study First Submitted: 2017-10-19
• Study First Submitted QC: 2017-10-23
• Last Update Submitted: 2017-10-23
• Study First Posted: 2017-10-26
• Last Update Posted: 2017-10-26
• Primary Completion: 2018-12-31
• Study Completion: 2018-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Enroll the chronic renal failure patients without dialysis in the department of nephrology of Affiliated Hospital of Xuzhou Medical University from January 2017 to December 2018.
• The patients enrolled were not treated with drugs that affect the renal blood flow and oxygen consumption, such as ACEI, ARB, calcium channel blockers, diuretics, vasodilators and other related factors within 2 weeks.

Exclusion Criteria

• Exclude those patients with diabetes, cardiovascular disease, severe infection, shock, dehydration, abnormal liver function, received glucocorticoid therapy, surgery and emergency dialysis.
• Eliminate those patients with respiratory disease(such as chronic obstructive pulmonary disease, bronchiectasis, asthma), cardiovascular diseases(such as acute and chronic cardiac insufficiency), blood system diseases (such as aplastic anemia, nutritional anemia and polycythemia vera).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	Control group	Treatment of chronic renal failure patients with conventional methods.
Treatment group	Treatment group	Adipose tissue-derived mesenchymal stem cells were used to treat patients with chronic renal failure.

Primary Outcome Measures

Name	Time	Method
serum creatinine	after 3 months of adipose tissue-derived mesenchymal stem cells treatment	intravenous blood sampling

Secondary Outcome Measures

Name	Time	Method
glomerular filtration rate	after 3 months of adipose tissue-derived mesenchymal stem cells treatment	emission computed tomography
apparent relaxation rate	after 3 months of adipose tissue-derived mesenchymal stem cells treatment	blood oxygen level dependent magnetic resonance imaging

Trial Locations

Locations (1)

The Affiliated Hospital of Xuzhou Medical University; 🇨🇳 Xuzhou, Jiangsu, China