The Biological Characteristics of Adipose Tissue-derived Mesenchymal Stem Cells and Its Role in the Treatment of Chronic Renal Failure
Overview
- Phase
- Not Applicable
- Intervention
- Treatment group
- Conditions
- Mesenchymal Stem Cells
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- serum creatinine
- Last Updated
- 8 years ago
Overview
Brief Summary
To investigate the biological characteristics of adipose tissue-derived mesenchymal stem cells(AMSCs) and its treatment effects on chronic renal failure.
Detailed Description
This study aims to investigate the biological characteristics of adipose tissue-derived mesenchymal stem cells(AMSCs) and its effect on oxidative stress, inflammation and mitochondrial damage.We intend to use blood oxygen level-dependent magnetic resonance imaging(BOLD-MRI), emission computed tomography(ECT) and enhanced magnetic resonance imaging to monitor renal oxygenation, tissue perfusion and renal function.Ultimately, we evaluate the treatment effects of AMSCs on chronic renal failure through these observations mentioned above.We hope to delay the progression of renal function in patients with chronic renal failure, and save huge social cost for dialysis by these research.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Enroll the chronic renal failure patients without dialysis in the department of nephrology of Affiliated Hospital of Xuzhou Medical University from January 2017 to December
- •The patients enrolled were not treated with drugs that affect the renal blood flow and oxygen consumption, such as ACEI, ARB, calcium channel blockers, diuretics, vasodilators and other related factors within 2 weeks.
Exclusion Criteria
- •Exclude those patients with diabetes, cardiovascular disease, severe infection, shock, dehydration, abnormal liver function, received glucocorticoid therapy, surgery and emergency dialysis.
- •Eliminate those patients with respiratory disease(such as chronic obstructive pulmonary disease, bronchiectasis, asthma), cardiovascular diseases(such as acute and chronic cardiac insufficiency), blood system diseases (such as aplastic anemia, nutritional anemia and polycythemia vera).
Arms & Interventions
Treatment group
Adipose tissue-derived mesenchymal stem cells were used to treat patients with chronic renal failure.
Intervention: Treatment group
Control group
Treatment of chronic renal failure patients with conventional methods.
Intervention: Control group
Outcomes
Primary Outcomes
serum creatinine
Time Frame: after 3 months of adipose tissue-derived mesenchymal stem cells treatment
intravenous blood sampling
Secondary Outcomes
- glomerular filtration rate(after 3 months of adipose tissue-derived mesenchymal stem cells treatment)
- apparent relaxation rate(after 3 months of adipose tissue-derived mesenchymal stem cells treatment)