Comparison of the Effect-site Concentration of Remifentanil for Insertion of the I-gel and Laryngeal Mask Airway During Propofol Anesthesia
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 41
- 试验地点
- 1
- 主要终点
- successful insertion of i-gel and LMA
研究概览
简要总结
Structural differences of supraglottic airway devices could influence the different compressive forces in the oropharyngeal cavities, and require different depth of anesthesia. The addition of remifentanil during propofol anesthesia facilitates the insertion of laryngeal mask airway (LMA) with minimal adverse hemodynamic disturbances. This study was designed to determine the effect-site concentration of remifentanil in 50% of patients (EC50) and 95% of patients (EC95) for successful i- gel insertion, and compare those for LMA insertion during propofol target-controlled infusion (TCI).
详细描述
Anesthesia was induced with propofol TCI at the effect-site concentration of 5 μg/ml, and the predetermined effect-site concentration of remifentanil was started simultaneously. The remifentanil concentration was determined using modified Dixon's up-and-down method (initial concentration: 3.0 ng/ml, step size: 0.5 ng/ml). Five minutes later, i- gel or LMA insertion was attempted. The response of the patients to the insertion of LMA was classified as either 'movement' or 'no movement'.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 19 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •ASA I-II patients undergoing general anesthesia for short elective surgery (<2 hr)
排除标准
- •G-E reflux
- •obesity (BMI>30)
- •anticipated difficult airway
研究组 & 干预措施
i-gel
I-gel insertion was attempted during propofol and remifentanil anesthesia .
干预措施: remifentanil (Drug)
i-gel
I-gel insertion was attempted during propofol and remifentanil anesthesia .
干预措施: i-gel (Device)
i-gel
I-gel insertion was attempted during propofol and remifentanil anesthesia .
干预措施: propofol (Drug)
laryngeal mask airway
LMA insertion was attempted during propofol and remifentanil anesthesia .
干预措施: remifentanil (Drug)
laryngeal mask airway
LMA insertion was attempted during propofol and remifentanil anesthesia .
干预措施: laryngeal mask airway (Device)
laryngeal mask airway
LMA insertion was attempted during propofol and remifentanil anesthesia .
干预措施: propofol (Drug)
结局指标
主要结局
successful insertion of i-gel and LMA
时间窗: from 5 min after anesthetic induction to 1min after device insertion
次要结局
未报告次要终点
研究者
Jong Yeop Kim
Associate professor
Ajou University School of Medicine