Open- and closed-label nocebo and placebo verbal suggestions regarding a sham transdermal patch: effects on itch
Completed
- Conditions
- Het onderzoek wordt bij gezonde proefpersonen uitgevoerd. Uitkomsten uit deze lijn van onderzoek bieden nieuwe handvatten voor verklaringsmodellen en therapeutische interventies voor aandoeningen waarbij jeuk een symptoom is.Not applicable
- Registration Number
- NL-OMON46396
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 112
Inclusion Criteria
Between 18 and 35 years old; good understanding of written and spoken Dutch
Exclusion Criteria
Refusal to give written informed consent; severe somatic or psychological morbidity (e.g., heart and lung diseases or DSM-IV psychiatric disorders) that would adversely affect participant*s safety or that might interfere with the study protocol; current chronic itch or pain complaints; current use of analgesics, anti-inflammatory drugs, antihistamines, or antibiotics; recent vaccinations; pregnancy; colour blindness
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is self-reported itch in response to histamine<br /><br>iontophoresis.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameters include expectations, self-reported and physical<br /><br>skin condition, and wellbeing (e.g., anxiety). In addition, effects of<br /><br>personality factors on expectation induction and study outcomes will be<br /><br>explored. Effects on response time on the Stroop test and Trail Making Test<br /><br>will be explored as well. </p><br>