ISRCTN54960762已完成不适用
IMIT-1: Lowering the Incidence of vascular complications with Metformin in patients with Impaired glucose Tolerance and a recent transient ischaemic attack or minor ischaemic stroke: a phase II randomised, controlled trial
Erasmus Medical Centre (The Netherlands)0 个研究点目标入组 40 人开始时间: 2007年4月11日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Men or women 18 years and over
- •2. TIA/minor ischaemic stroke (modified Rankin Score three or less) within six months
- •3. Impaired fasting glucose (fasting glucose level of 5.6 to 6.9 mmol/L) and/or impaired glucose tolerance (two-hour post-load glucose level of 7.8 to 11.0 mmol/L)
- •4. Informed consent
排除标准
- •1. Known or newly diagnosed diabetes mellitus
- •2. Contraindication for metformin:
- •2.1. Renal impairment (serum creatinine greater than 135 micromol/L for men, and greater than 110 micromol/L for women)
- •2.2. Hepatic disease (liver enzymes increased twice the upper limit of normal)
- •2.3. A past history of lactic acidosis
- •2.4. Cardiac failure requiring pharmacological therapy
- •2.5. Chronic hypoxic lung disease
- •2.6. Pregnancy
- •2.7. Breast feeding
- •3. Severe comorbidity interfering with follow-up
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