Effects of Energy-Restricted Diet and Whole-Body Electromyostimulation (WB-EMS) on Myokine-Adipokine Interaction, Appetite Regulation, and Body Composition in Obese Individuals: A Randomized Controlled Trial
概览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- Firat University
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Change in serum irisin levels
概览
简要总结
Obesity is a major global health problem associated with metabolic dysfunction, altered adipokine signaling, and impaired appetite regulation. Conventional weight loss strategies such as calorie restriction often result in compensatory physiological adaptations, including increased appetite and loss of lean body mass, which may limit long-term effectiveness.
Whole-body electromyostimulation (WB-EMS) is an emerging, time-efficient intervention that induces simultaneous muscle activation and may improve metabolic health. However, the underlying molecular mechanisms, particularly the interaction between myokines and adipokines, remain insufficiently understood.
This randomized controlled trial aims to investigate the effects of an energy-restricted diet combined with WB-EMS on myokine-adipokine interaction, appetite regulation, and body composition in obese individuals. Participants will be randomly assigned to either a diet-only group or a diet plus WB-EMS group for 8 weeks.
Primary outcomes include changes in serum irisin levels. Secondary outcomes include myostatin, leptin, adiponectin, FGF-21, ghrelin, GLP-1, body composition parameters, and eating behavior. The findings of this study are expected to provide novel insights into the physiological and molecular effects of WB-EMS as a complementary strategy in obesity management.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18 and 65 years
- •Body mass index (BMI) ≥ 30 kg/m²
- •Sedentary lifestyle (less than 2 hours of structured exercise per week)
- •Willingness to participate and provide written informed consent
排除标准
- •Presence of pacemaker or implantable cardioverter-defibrillator
- •Known cardiovascular disease or severe chronic illness
- •Pregnancy or breastfeeding
- •Uncontrolled diabetes or severe metabolic disorders
- •Active malignancy or cancer treatment
- •Severe renal or hepatic failure
- •Acute infection or inflammatory disease
- •Orthopedic conditions limiting physical activity
- •Use of medications affecting body composition or appetite (e.g., corticosteroids, weight-loss drugs)
- •Regular resistance training within the last 3 months
研究组 & 干预措施
Diet Only
Participants receive an individualized energy-restricted diet program.
干预措施: Energy-Restricted Diet (Behavioral)
Diet + WB-EMS
Participants receive an energy-restricted diet combined with whole-body electromyostimulation (WB-EMS).
干预措施: Energy-Restricted Diet (Behavioral)
Diet + WB-EMS
Participants receive an energy-restricted diet combined with whole-body electromyostimulation (WB-EMS).
干预措施: Whole-Body Electromyostimulation (WB-EMS) (Device)
结局指标
主要结局
Change in serum irisin levels
时间窗: Baseline to 8 weeks
Assessment of change in circulating irisin levels measured by ELISA.
次要结局
- Change in serum myostatin levels(Baseline to 8 weeks)
- Change in serum leptin levels(Baseline to 8 weeks)
- Change in serum adiponectin levels(Baseline to 8 weeks)
- Change in serum FGF-21 levels(Baseline to 8 weeks)
- Change in serum ghrelin levels(Baseline to 8 weeks)
- Change in serum GLP-1 levels(Baseline to 8 weeks)
- Change in body composition(Baseline to 8 weeks)
- Change in eating behavior scores(Baseline to 8 weeks)
研究者
Murat Açık
Assistant Professor, PhD
Firat University