eonatal respiratory distress syndrome after repeat exposure to antenatal corticosteroids: a randomised controlled trial
Phase 3
Completed
- Conditions
- Women at risk of preterm birth, at less than 32 weeks gestation, who have already received a course of prenatal corticosteroids.Reproductive Health and Childbirth - Fetal medicine and complications of pregnancyReproductive Health and Childbirth - Antenatal care
- Registration Number
- ACTRN12606000318583
- Lead Sponsor
- Professor Caroline Crowther
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 980
Inclusion Criteria
Singleton, twin or triplet pregnancy; <32 weeks gestation; > or = 7 days since first corticosteroid treatment, remaining at risk of preterm delivery; informed written signed consent given.
Exclusion Criteria
Women with chrioamnionitis requiring urgent delivery; Women in whom L/S ratio or equivalent test is judged mature; Women in 2nd stage labour; Women in whom corticosteroid therapy is considered essential.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method eonatal lung disease[Diagnosed in neonatal period up to hospital discharge];Weight, length and head circumference[Measured at birth and primary hospital discharge.]
- Secondary Outcome Measures
Name Time Method Maternal infection[Measured in the antenatal, intrapartum and postnatal periods.];Maternal quality of life[Measured at 6 months post-partum];Other neonatal morbidity[Diagnosed in neonatal period up to hospital discharge.]