Association of OR6A2 Expression on Monocytes With Inflammation and Major Adverse Cardiovascular Events in Myocardial Ischemia-Reperfusion Injury
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Major Adverse Cardiovascular Events
研究概览
简要总结
This study examines how the interaction between octanal (an OR6A2 receptor activator) and OR6A2 expression influences inflammation and clinical outcomes in Myocardial Ischemia-Reperfusion Injury patients. We analyze two key relationships: 1) The octanal-OR6A2 pathway's association with systemic oxidative stress/inflammatory biomarkers, and 2) How OR6A2 expression patterns on monocyte subtypes and plasma octanal levels correlate with major cardiovascular events. Patients undergoing this post-revascularization injury provided blood samples for OR6A2/octanal/inflammation measurements. IR Injury patients underwent 44-month clinical follow-up. Results may identify biological markers for personalized risk assessment after revascularization therapies. Ethics approval: Zhongda Hospital #2020ZDSYLL051-P01.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute myocardial infarction (AMI) patients with angiographically-confirmed coronary artery disease undergoing primary percutaneous coronary intervention (PCI), and subsequently diagnosed with protocol-defined myocardial ischemia-reperfusion injury during the post-PCI period.
- •Age 18-90 years inclusive.
排除标准
- •Active systemic infections.
- •Advanced heart failure (NYHA class III-IV).
- •Acute cerebrovascular conditions.
- •Active myocarditis.
- •cardiomyopathy.
- •Refractory ventricular tachycardia/fibrillation.
- •Diagnosis/concurrent treatment for malignancy within 5 years (except non-melanoma skin cancer/carcinoma in situ).
- •Severe renal insufficiency (estimated glomerular filtration rate [eGFR] <30 mL/min/1.73m2 or dialysis dependence).
- •Child-Pugh class C hepatic dysfunction.
结局指标
主要结局
Major Adverse Cardiovascular Events
时间窗: From enrollment to 44 months after reperfusion injury
Major Adverse Cardiovascular Events (MACEs) defined as the composite endpoint of recurrent acute myocardial infarction, cardiac death, stroke, hospitalization for unstable angina, or unplanned coronary revascularization.
次要结局
- Serum IL-1α Level(Baseline (within 24 hours after confirmed myocardial ischemia-reperfusion injury))
- Serum IL-1β Level(Baseline (within 24 hours after confirmed myocardial ischemia-reperfusion injury))
- Plasma Malondialdehyde (MDA) Level(Baseline (within 24 hours after confirmed myocardial ischemia-reperfusion injury))
- Plasma Hydrogen Peroxide (H₂O₂) Level(Baseline (within 24 hours after confirmed myocardial ischemia-reperfusion injury))
研究者
Genshan Ma
Director of Cardiovascular Medicine & Deputy Director of Cardiovascular Disease Research Institute, Zhongda Hospital Southeast University; Professor (Level-II); Chief Physician; PhD Advisor; Chairman, Cardiovascular Society of Jiangsu Medical Association
Southeast University, China