Serum Omentin-1 and Carotid Atherosclerosis In Non-Diabetic Chronic Kidney Disease

• Conditions: Non-diabetic Chronic Kidney Disease; Atherosclerosis

• Registration Number: NCT01701830
• Lead Sponsor: Kocaeli Derince Education and Research Hospital

Brief Summary

The aim of the study is to evaluate whether a low level of serum omentin-1 is associated with carotid atherosclerosis and mediated by inflammation.

Detailed Description

Atherosclerotic cardiovascular disease is markedly increased in chronic kidney disease. There are a lot of risk factor, along with conventional risk factors. Serum onemtin-1 is a adipokine and suggested as a new marker for vascular disease.It has some anti-atherogenic properties. Studies investigating serum omentin-1 level have usually conducted in patients with diabetes mellitus.

Study Timeline

• Status Verified: 2012-10
• Study Start: 2012-10
• Study First Submitted: 2012-10-03
• Study First Submitted QC: 2012-10-04
• Last Update Submitted: 2012-10-04
• Study First Posted: 2012-10-05
• Last Update Posted: 2012-10-05
• Study Completion: 2013-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 85

Inclusion Criteria

• between ages of 18 - 65 years old chronic kidney disease of stage 3-4

Exclusion Criteria

• Chronic kidney disease of stage 5
• The history of ischemic cardiovascular disease (myocardial infarction, unstable angina, stroke, peripheral artery disease, or cardiovascular revascularization)
• Severe heart failure
• Stage 2 hypertension
• Diabetes mellitus
• Corticosteroid therapy
• Severe hepatic disease
• Smoking
• Inflammatory disease
• Acute infectious disease
• Malignancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Department of Nephrology, Check-up Clinic,Kocaeli Derince Education and Traning Hospital; 🇹🇷 Izmit, Kocaeli, Turkey