Comparison of two iv fluids used for fluid management randomly and observe the effects on acid base and electrolyte disturbances in critically ill children.
Not Applicable
Completed
- Conditions
- Health Condition 1: R799- Abnormal finding of blood chemistry, unspecified
- Registration Number
- CTRI/2022/09/045167
- Lead Sponsor
- St Stephens Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
1.All patients from 1 month upto 12 years with hypoperfusion admitted in PICU requiring fluid resuscitation and maintenance fluid.
2.Patients who will receive fluid boluses in emergency, pediatric ward, post ICU and thereafter shifted to PICU.
Exclusion Criteria
All the patients
1.With head injury.
2.chronic kidney disease with hyperkalemia
With Burns
3.Children already on maintenance fluid requiring resuscitation.
4.whose parents refused consent.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method a.Acid base imbalance and occurrence of hyperchloremia.- pH and base excess will be measured. Normal pH range will be taken as 7.35-7.45 and normal base excess for infants will be -7 to -1, for children it will be -4 to +2. Normal serum chloride levels as per lab of the study hospital. <br/ ><br>b.Sodium and potassium disturbance – Hypernatremia is defined by serum sodium concentration more than 145meq/l and hyponatremia by serum sodium concentration 135meq/l. <br/ ><br>Timepoint: At baseline, 12 hours, 24 hours thereafter as when required till 72 hours <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1.Incidence of Acute kidney injury- Acute kidney injury is defined by KDIGO criteria <br/ ><br>2.Coagulopathy- PT, APTT, INR will be measured and assessed by standard lab values. <br/ ><br>3.Duration of PICU and hospital stay: will be calculated in days. <br/ ><br>Timepoint: At admission, at 12 hours,24 hours