Alzheimer's disease: Correlation of plasma biomarkers and clinical diagnosis in memory clinic patients.

• Conditions: G30.9; F06.7; Alzheimer disease, unspecified; Mild cognitive disorder

• Registration Number: DRKS00023471
• Lead Sponsor: Direktor der Klinik für Psychiatrie und Psychotherapie Universitätsklinikum Köln (AöR)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-03-15
• Study Completion: 2022-05-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

We include patients who have registered with memory disorders at the Center for Memory Disorders (ZfG) of the Clinic for Psychiatry and Psychotherapy at the University Hospital of Cologne and who have given written consent to give a blood sample for research purposes.

Exclusion Criteria

Patients who refuse to have their blood drawn for research purposes are excluded. Further exclusion criteria are not defined.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The aim of this work is the analysis of research blood samples of the Center for Memory Disorders for the determination of plasma Aß40, Aß42, Aß42/Aß40, Aß42xTau, t-Tau, p-tau181 and NFL and the comparison between SCD, MCI and DAT to investigate whether the biomarkers in plasma are suitable for the diagnosis of the different diagnostic groups. For this purpose, the protein concentrations of the plasma samples are determined using SIMOA-HD analyzers.

Secondary Outcome Measures

Name	Time	Method
Comparison of plasma biomarkers with different diagnostic tools, such as neuropsychological testing and cerebrospinal fluid (CSF) diagnostics. For this purpose, statistical comparison using linear regression and ROC analyses will be sought.