Inspiratory Muscle Strength Training to Improve Blood Pressure and Physiological Function
- Conditions
- HypertensionAgingPrehypertension
- Interventions
- Other: Inspiratory muscle strength trainingOther: Sham training
- Registration Number
- NCT03266510
- Lead Sponsor
- Douglas Seals
- Brief Summary
The purpose of this study is to assess the efficacy of inspiratory muscle strength training for lowering blood pressure and improving physiological function (vascular, motor, and cognitive) in middle-aged and older adults with elevated systolic blood pressure.
- Detailed Description
Over, the proposed research project has the long-term potential to influence clinical practice by establishing a novel lifestyle intervention for treating multiple domains of age- and hypertension-associated physiological dysfunction and thereby reducing the risk of clinical disease and disability.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 64
- Ability to provide informed consent
- Willing to accept random assignment to condition
- Women will be confirmed as postmenopausal (either natural or surgical) based on cessation of menses for >1 year.
- Resting systolic blood pressure 120-159 mmHg
- Resting diastolic blood pressure <100 mmHg
- Subjects taking anti-hypertensive medications will be included provided they meet the other inclusion criteria, including elevated systolic blood pressure. These medications will not be withheld prior to experimental protocols.
- Free from alcohol dependence or abuse, as defined by the American Psychiatry Association, Diagnostic and Statistical Manual or Mental Disorders (DSM-IV)
- Current smoking
- Chronic clinical disease (e.g., inflammatory bowel disease/irritable bowel syndrome, coronary artery/peripheral artery/cerebrovascular diseases, diabetes, chronic kidney disease requiring dialysis, neurological disorders or diseases that may affect motor/cognitive function [multiple sclerosis, Parkinson's disease, polio, Alzheimer's disease, dementia, or other brain diseases of aging]), except hypertension
- Postmenopausal <1 year
- Scoring <21 on the mini-mental state examination
- Moderate or sever peripheral artery disease (ankle-brachial index 0.7)
- Taking a medication that your doctor deems unsafe to hold for >1 week
- A graded exercise test will be performed by all subjects. If there is physician concern or an adverse event, the subject will not participate in the study.
- No weight stable in the prior 3 months (>2 kg weight change) or unwilling to remain weight stable throughout study (rationale: recent weight change or weight loss can influence vascular function)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Inspiratory muscle strength training Inspiratory muscle strength training Using a handheld device, subjects were perform 30 breaths a day, six days a week. The device produces resistance that increases the effort of breathing in. The resistance to breathing will be strong. Sham training Sham training Using a handheld device, subjects were perform 30 breaths a day, six days a week. The device produces resistance that increases the effort of breathing in. The resistance to breathing will be weak.
- Primary Outcome Measures
Name Time Method Blood pressure 6 weeks Resting blood pressure
- Secondary Outcome Measures
Name Time Method Ambulatory blood pressure 6 weeks 24-hour mean blood pressure
Systemic markers of oxidative stress 6 weeks Oxidized LDL levels in blood
Endothelial cell markers of oxidative stress 6 weeks Nitrotyrosine levels in biopsied endothelial cells
Endothelium-dependent dilation 6 weeks Flow-mediated dilation
Arterial stiffness 6 weeks Aortic pulse wave velocity
Motor function 6 weeks NIH Toolbox motor test battery
Cognitive function 6 weeks NIH Toolbox cognition test battery
Trial Locations
- Locations (1)
Integrative Physiology of Aging Laboratory
🇺🇸Boulder, Colorado, United States