The Canadian preterm labour nitroglycerin trial

Completed

• Conditions: Preterm labour; Pregnancy and Childbirth

• Registration Number: ISRCTN20129681
• Lead Sponsor: Queen's University (Canada)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-09-26
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 600

Inclusion Criteria

1. Greater than or equal to 24 to less than or equal to 32 weeks gestational age based on menstrual dates or earliest ultrasound scan
2. Preterm labour:
2.1. At least four painful uterine contractions per 20 minutes
2.2. Change in the cervix (change in bishop score or bishop score greater than or equal to 6)

Exclusion Criteria

1. Any maternal (e.g. significant antepartum haemorrhage) or foetal (e.g. non-reassuring heart rate pattern) condition necessitating immediate delivery
2. Multiple gestations (i.e. twins, triplets etc.)
3. Premature prelabour rupture of the membranes (PPROM)
4. Intrauterine foetal demise or lethal foetal anomalies
5. Cervix dilated greater than 8 cm
6. Treatment with another agent within 24 hours
7. Previous enrolment in this trial
8. Known sensitivity to GTN
9. Failure to give consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified