Circulating Tumor DNA to Monitor Response to Neoadjuvant Chemotherapy in Breast Cancer
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Breast Cancer
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- death of breast cancer
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Investigators aim to investigate whether circulating tumor DNA is a sensitive marker to evaluate patients' response to neoadjuvant chemotherapy
Detailed Description
Neoadjuvant chemotherapy(NAC) is traditionally for locally advanced disease, converting an inoperable to a resectable tumor.In recent years, it has become an option for patients of lower tumor stage to increase the possibility of breast conserving therapy. An effective method to monitor the response to NAC is important.
Investigators
Liu Qiang
Professor
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Eligibility Criteria
Inclusion Criteria
- •Female patients undergoing NAC
- •Age: 18-70 yrs
- •Any menopausal status
- •Any hormal receptor status
Exclusion Criteria
- •Metastasis discovered during NAC
- •Lost more than 2 blood samples during NAC and surgery
Outcomes
Primary Outcomes
death of breast cancer
Time Frame: Follow-up time is estimated to be up to 5 years. The duration is from the date of diagnosis to date of death of breast cancer or date of death of any cause, whichever come first.
The event is defined as death of breast cancer, which is a separate measure
Secondary Outcomes
- tumor recurrence or distant metastasis(Follow-up time is estimated to be up to 5 years.The duration is from diagnosis to local recurrence or distant metastasis of breast cancer. Patients were followed up every six months in first three years, then followed up once a year.)