Serologic surveillance of SARS-CoV-2 during the 2020 pandemic in exposed and unexposed healthcare workers in an academic hospital in Amsterdam

Recruiting

Conditions: corona
COVID-19
SARS-CoV2
10047438

Registration Number: NL-OMON56239

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 864

Inclusion Criteria

1. Individual:
a. health care personnel (physicians and nurses) from participating
hospitals having (or expect within 4 weeks to have) direct patient contact with
patients suspected for COVID-19 or with confirmed COVID-19 disease (exposure
group)
b. control group of health care personnel (administrative, policy and
medical personnel without any patient contact) from participating hospital
without direct contact with patients or contact with patients* direct
environment (e.g. patient room, bed, instruments) (unexposed group)
c: nurses and physicians in direct patiient care for non-COVID-19 patients
2. Informed consent;
3. Age >18 years

Exclusion Criteria

1. Insufficient competency in Dutch to such an extent that it prevents
sufficient comprehension of the participant information letter

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- presence of SARS-CoV-2 antibody (IgM, IgG) titres</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Presence of antibodies (IgG) to other corona-viruses<br /><br>Survey information about work conditions, exposures, infection symptoms.<br /><br>B and Tcell reactivity<br /><br>Immune response to vaccine<br /><br>Psychological signs and symptoms<br /><br>Impact of COVID-19 measures on mental health, resilience and job satisfaction.</p><br>