Sero-surveillance SARS-CoV-2
Recruiting
- Conditions
- COVID-19, humane coronaviruses NL63, 229E, OC43, HKU1
- Registration Number
- NL-OMON26401
- Lead Sponsor
- Amsterdam UMC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 800
Inclusion Criteria
Exposed group: nurses & physicians caring for suspected or confirmed current COVID-19 patients on a COVID-19 unit, ICU or emergency ward.
Intermediate group: nurses & physicians caring for patients without suspected or confirmed current COVID-19 (in contrast to the other groups, this group is only measured once)
Control group: hospital personnel not working in patient care
Exclusion Criteria
Age <18 years old.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method prevalence and time to SARS-CoV-2 seroconversion (IgG and/or IgM) compared between groups. We will test for differences between groups (dichotomous & survival data), assuming a 10% minimally relevant difference. If groups are not statistically different we will use non-inferiority analysis methods to test whether the difference between groups is within the non-inferiority margin of 10%.
- Secondary Outcome Measures
Name Time Method presence of non-SARS-CoV-2 coronavirus antibodies and its association with SARS-CoV-2 seroconversion and disease severity. Influence of self-reported exposure to COVID-19 patients as a continuous determinant on SARS-CoV-2 seroconversion.