1,5-Anhydro-D-Glucitol Can Reflect Hypoglycemia in Patients With Well Controlled Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- The correlation between 1,5-anhydro-D-glucitol and Modified Hypoglycemic score
研究概览
简要总结
The purpose of this study is to evaluate the usefulness of plasma 1,5-anhydro-D-glucitol (1,5-AG) as a novel surrogate marker of hypoglycemia
详细描述
We enrolled well controlled diabetes patients who had hypoglycemic event at least one time more. All patients assess the risk of severe hypoglycemia and hypoglycemic unawareness using hypoglycemic awareness questionnaires (HYPO score). The patients who are treated with insulin agent were inserted sensor of continuous glucose monitoring systems under the skin during three days. We were analysed the correlation between 1,5-anhydro-D-glucitol and HYPO score.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients attending outpatients of department of endocrinology and metabolism, seoul national university hospital .(HbA1C <8%)
- •The patients who treated with insulin or sulfonylureas at least 3month period
- •In case fo sulfonylurea user, HbA1c was restricted under 8%
- •The patients who had hypoglycemic event at least 3 months
- •who has can be survey questionnaire
- •who can insert continuous glucose monitoring system
排除标准
- •renal dysfunction patients
- •hepatic dysfunction patients
- •who has any kind of diseases, operations, medical treatments that can affect glucose levels
结局指标
主要结局
The correlation between 1,5-anhydro-D-glucitol and Modified Hypoglycemic score
时间窗: within the least 3 months
Modified hypoglycemic score was calculated by modified Clarke et al. questionnaire.
次要结局
- The relation between glycemic variability indices such as MAGE of continuous glucose monitoring system and 1,5-AG in insulin using patients.(within at least 3months)
- The correlation between hypoglycemic percent of Continuous glucose monitoring system and modified hypoglycemic score in insulin using patients.(within at leat 3months)
研究者
Hye Seung Jung
associate professor
Seoul National University Hospital