Effects of Adding Dexamethasone Plus Ketamine to Bupivacaine for Ultrasound Guided Serratus Plane Block as Analgesia in Major Breast Surgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Post ooerative analgesia requirment
研究概览
简要总结
This randomized, double-blind trial included 60 female patients undergoing modified radical mastectomy. The study carried out at National Cancer Institute, cairo university after approval of the local ethical committee.
The study aiming to compare the analgesic efficiency of adding dexamethasone or ketamine plus dexamethasone to bupivacaine in ultrasound-guided serratus anterior plane block (SAPB) performed with modified radical mastectomy surgery.
详细描述
They will randomly assigned to two groups of 30 patients each, at 1:1 allocation ratio using computer-generated random numbers concealed in sealed opaque envelopes.
Group (A):
Patients will receive ultrasound-guided serratus anterior block using 30ml of (bupivacaine 0 .25 % and dexamethasone 4 mg).
Group (B):
Patients will receive ultrasound-guided serratus anterior block using 30ml of (bupivacaine 0.25% and dexamethasone 4mg with ketamine 50 mg).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •All female patient undergoing modified radical mastectomy
- •Age from 20 to 60 years
- •ASA physical status I,II and III class
排除标准
- •Refusal for SAPB.
- •Defective coagulation.
- •Infection at the site of injection.
- •History of allergy to the study drugs
结局指标
主要结局
Post ooerative analgesia requirment
时间窗: 24 hours
Total post-operative morphine consumption over the first 24 hours post-operative and difference between two groups.
Time of first analgesic request
时间窗: 24 hours
The time to first request of analgesic postoperatively and difference between two groups.
次要结局
未报告次要终点
研究者
Ahmed Fakher Mohamed Abdou
Dr
National Cancer Institute, Egypt