Comparative Evaluation of Adding Dexamethasone to 2% Lidocaine (With and Without Epinephrine) on the Anesthetic Success Rate of Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis
Overview
- Phase
- Not Applicable
- Intervention
- Lidocaine Hydrochloride
- Conditions
- Pulpitis - Irreversible
- Sponsor
- Jamia Millia Islamia
- Enrollment
- 124
- Locations
- 1
- Primary Endpoint
- Anesthtic success
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
This randomized, double-blind clinical trial aimed at the evaluation of the effect of adding dexamethasone to 2% lidocaine, given as inferior alveolar nerve block in the endodontic management of symptomatic irreversible pulpitis. One hundred and twenty four patients received one of the three IANB injections before the endodontic treatment: 2% lidocaine with 1:80 000 epinephrine; 2% lidocaine with 1:80 000 epinephrine mixed with 2mg dexamethasone; and plain 2% lidocaine mixed with 2mg dexamethasone. The anesthetia was considered successful if the patients experienced no pain or faint/weak/mild pain during root canal access preparation and instrumentation (HP VAS score <55 mm). The effect of intraligamentary injections on maximum heart rates was also recorded.
Investigators
Dr. Vivek Aggarwal
Professor
Jamia Millia Islamia
Eligibility Criteria
Inclusion Criteria
- •absence of any periapical radiolucency on radiographs, except for a widened periodontal ligament
- •active pain in a mandibular molar
- •prolonged response to cold testing with an ice stick and an electric pulp tester
- •vital coronal pulp on access opening and ability to understand the use of pain scales
Exclusion Criteria
- •a history of known or suspected drug abuse
- •history of active peptic ulcer within the preceding 12 months
- •history of bleeding problems or anticoagulant use within the last month
- •known allergy, sensitivity, or contraindications to any opioid or nonopioid analgesic including aspirin or NSAIDs
- •patients who had taken NSAIDs within 12 h before administration of the study drugs
- •patients who were pregnant or breast-feeding
Arms & Interventions
Inferior Alveolar nerve block with 2% lidocaine with 1:80 000 epinephrine
An Inferior Alveolar nerve block was given with 2% lidocaine with 1:80 000 epinephrine
Intervention: Lidocaine Hydrochloride
Inferior Alveolar nerve block with 2% lidocaine with 1:80 000 epinephrine with 2mg dexamethasone
An Inferior Alveolar nerve block was given with 2% lidocaine with 1:80 000 epinephrine mixed with 2mg dexamethasone
Intervention: Lidocaine Hydrochloride
Inferior Alveolar nerve block with plain 2% lidocaine mixed with 2mg dexamethasone
An Inferior Alveolar nerve block was given with plain 2% lidocaine mixed with 2mg dexamethasone
Intervention: Lidocaine Hydrochloride
Outcomes
Primary Outcomes
Anesthtic success
Time Frame: 15 minutes after the inferior alveolar nerve block
Pain during the endodontic treatment was assessed using a visual analog scale (Heft-Parker VAS). Success was defined as no or mild pain (pain score≤54mm on Hp VAS) during access preparation and root canal instrumentation.
Secondary Outcomes
- Heart Rate(After 1 minutes of initial injection)