Comparative Evaluation of Adding Dexamethasone to 2% Lidocaine (With and Without Epinephrine) on the Anesthetic Success Rate of Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 124
- 试验地点
- 1
- 主要终点
- Anesthtic success
研究概览
简要总结
This randomized, double-blind clinical trial aimed at the evaluation of the effect of adding dexamethasone to 2% lidocaine, given as inferior alveolar nerve block in the endodontic management of symptomatic irreversible pulpitis. One hundred and twenty four patients received one of the three IANB injections before the endodontic treatment: 2% lidocaine with 1:80 000 epinephrine; 2% lidocaine with 1:80 000 epinephrine mixed with 2mg dexamethasone; and plain 2% lidocaine mixed with 2mg dexamethasone. The anesthetia was considered successful if the patients experienced no pain or faint/weak/mild pain during root canal access preparation and instrumentation (HP VAS score <55 mm). The effect of intraligamentary injections on maximum heart rates was also recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 59 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •absence of any periapical radiolucency on radiographs, except for a widened periodontal ligament
- •active pain in a mandibular molar
- •prolonged response to cold testing with an ice stick and an electric pulp tester
- •vital coronal pulp on access opening and ability to understand the use of pain scales
排除标准
- •a history of known or suspected drug abuse
- •history of active peptic ulcer within the preceding 12 months
- •history of bleeding problems or anticoagulant use within the last month
- •known allergy, sensitivity, or contraindications to any opioid or nonopioid analgesic including aspirin or NSAIDs
- •patients who had taken NSAIDs within 12 h before administration of the study drugs
- •patients who were pregnant or breast-feeding
研究组 & 干预措施
Inferior Alveolar nerve block with 2% lidocaine with 1:80 000 epinephrine
An Inferior Alveolar nerve block was given with 2% lidocaine with 1:80 000 epinephrine
干预措施: Lidocaine Hydrochloride (Drug)
Inferior Alveolar nerve block with 2% lidocaine with 1:80 000 epinephrine with 2mg dexamethasone
An Inferior Alveolar nerve block was given with 2% lidocaine with 1:80 000 epinephrine mixed with 2mg dexamethasone
干预措施: Lidocaine Hydrochloride (Drug)
Inferior Alveolar nerve block with plain 2% lidocaine mixed with 2mg dexamethasone
An Inferior Alveolar nerve block was given with plain 2% lidocaine mixed with 2mg dexamethasone
干预措施: Lidocaine Hydrochloride (Drug)
结局指标
主要结局
Anesthtic success
时间窗: 15 minutes after the inferior alveolar nerve block
Pain during the endodontic treatment was assessed using a visual analog scale (Heft-Parker VAS). Success was defined as no or mild pain (pain score≤54mm on Hp VAS) during access preparation and root canal instrumentation.
次要结局
- Heart Rate(After 1 minutes of initial injection)
研究者
Dr. Vivek Aggarwal
Professor
Jamia Millia Islamia