Coronary changes and cardiac events in children diagnosed with kawasaki disease without initial coronary aneurysm: A multicenter retrospective cohort study
- Conditions
- Kawasaki disease (KD) is a common vasculitis in childhood. Coronary artery aneurysms (CAAs) are major complication especially in patients who left untreated. Serial echocardiography at initial diagnosis, 2 weeks and 8 weeks after onset is recommended but may be more frequent if CAAs develop. However, the echocardiography at 2 weeks in patients who had no CAAs on the initial echocardiography often show no progression on the observation.Kawasaki disease
- Registration Number
- TCTR20210603001
- Lead Sponsor
- /A
- Brief Summary
ew CAA in patients with KD who had no previous CAA in their initial echocardiography are rare. In addition, patients who had normal echocardiographic follow up at two weeks or eight weeks mostly continued to be normal at one year. The optimal timing of the echocardiographic follow up should be at two to eight weeks in patients without initial CAA, who still have a coronary artery Z score less than 2 at the second echocardiography.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 126
All children age 1 month to 18 years old who had KD without CAAs on initial echocardiography in Siriraj hospital, Nakornpathom hospital, Prapokkloa Chantaburi hospital, Choaphrayayommarat Hospital between July 1st, 2017 and March 31st, 2020
1. Patients who had incomplete data of echocardiography at initial diagnosis, 2 weeks and 8 weeks.
2. Patients who had congenital heart disease
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change of coronary to CAA at 2 weeks and 8 weeks post onset Present or absent
- Secondary Outcome Measures
Name Time Method Presence of major cardiac adverse events at 1 year post onset Present or absent