Cardiovascular risk profile in pediatric CAH patients: a cross-sectional study

• Conditions: Congenital aderenal hyperplasia; 10001353

• Registration Number: NL-OMON38496
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

CAH due to 21-hydroxylase deficiency, biochemical and genetically proven
Age: 1-16 years

Exclusion Criteria

CAH due to other enzym deficiency
Refusal to participate by patient/parents
Known co-morbidity: cardiac disease, renal disease, co-medication that interferes with blood pressure

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Comparisson of the different cardiovascular riskfactors between CAH patients<br /><br>and reference values.<br /><br>- Insulin resistance<br /><br>- left ventricular hypertrophy<br /><br>- intima media thickness<br /><br>- body composition<br /><br>- 24-h systolic and diastolic bloodpressure<br /><br>- 24-h urinary steroid profile<br /><br>- circulating biochemical risk markers (e.g. lipids)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-</p><br>