NCT00466687已完成2 期
A Phase II Trial of Tarceva (Erlotinib) and Avastin (Bevacizumab) in the Treatment of Patients With Metastatic Melanoma
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 4
- 主要终点
- Number of Patients With Response
研究概览
简要总结
RATIONALE: Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Giving erlotinib together with bevacizumab may kill more tumor cells.
PURPOSE: This phase II trial is studying how well giving erlotinib together with bevacizumab works in treating patients with stage IV melanoma.
详细描述
OBJECTIVES:
Primary
- Determine the overall response rate, response duration, and frequency of progression-free survival at 6 months in patients with stage IV melanoma treated with erlotinib hydrochloride and bevacizumab.
- Determine objective responses in patients treated with this regimen.
Secondary
- Determine the overall safety and tolerability of this regimen in these patients.
- Evaluate tissue blocks for EGFR by monoclonal antibody H11 (DAKO) or fluorescence in situ hybridization(FISH)7p12-specific probe-overexpression or amplification in patients treated with this regimen.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Measurable Stage IV melanoma
- •Easter Cooperative Oncology Group (ECOG) Performance Status must be 0-1
- •Good organ function as demonstrated by, Creatinine <2.mg/dl, AST or ALT <5 times upper limit of normal for subjects with documented liver metastases; <2.5 times the upper limit of normal (ULN) for subjects without evidence of liver metastases, bilirubin<2.0mg/dl,, absolute neutrophil count (ANC)>1500/ul, platelets>75k/ul, hemoglobin (Hgb)>9 (may be transfused to obtain)
- •Prior therapy: adjuvant interferon (IFN) allowed; no more than one prior regimen for advanced stage IV disease
- •Patients must have a life expectancy of >3 months
- •Patients with brain metastases are eligible only if they fulfill the following: resected or stereotactic treatment a minimum of 3 months previously and no active CNS disease since then; brain metastases treated greater than 6 months ago without evidence of progression or hemorrhage, <1cm in size per lesion (up to 3 lesions), and off all steroids
- •Patients may not have received other agents, either investigational or marketed, which act by either EGFr inhibition or anti-angiogenesis mechanisms. Other epidermal growth factor receptor (EGFR) inhibitors include (but are not limited to): Iressa, erbitux, CI-
- •Angiogenesis inhibitors include (but are not limited to): SU5416, SU6668, SU 0122348, CP547632, VEGF Trap, anti-integrin αVβ
- •Recovered from toxicity of major surgery (4 wks), chemotherapy or biologic therapy (4 wks), and/or radiation therapy (2 wks)
- •No active other malignancy within 12 months
- •No active systemic infection
- •Over age of 18 years and signed IRB approved informed consent
排除标准
- •Subjects meeting any of the following criteria (3.2.2-3.2.16) are ineligible for study entry
- •Compromised renal or hepatic function as defined by Creatinine >2.0mg/dl, aspartate transaminase (AST) or alanine transaminase (ALT) >5 times upper limit of normal for subjects with documented liver metastases; >2.5 times the upper limit of normal (ULN) for subjects without evidence of liver metastases
- •Patient may not be part of any other investigational studies
- •internationalized normal ratio (INR) > 1.5
- •Patients with PEG or G-tube are ineligible.
- •Major surgical procedure, open biopsy; or significant traumatic injury within 28 days, or anticipation of need for major surgical procedure during the course of the study
- •Any non-healing wound, ulcer, or bone fracture.
- •Any clinical evidence or history of a bleeding diathesis or coagulopathy.
- •Patients with a history of deep vein thrombosis or thromboembolic disease within the past 6 months.
- •History of acute myocardial infarction within 6 months. In addition, patients are ineligible if they have clinically significant cardiovascular disease ((e.g., uncontrolled hypertension [blood pressure of >160/110 mmHg on medication], New York Heart Association (NYHA) Grade II or greater congestive heart failure, serious cardiac dysrhythmia requiring medication, or peripheral vascular disease (Grade II or greater)
- •Patients with > 1+ proteinuria will have 24-hour urine collection; for protein. Patients with ≥ 1gm protein/24 hrs will be excluded
- •If child bearing age must not be pregnant or nursing and use methods to prevent pregnancy
- •History or evidence upon physical examination of central nervous system (CNS) disease (e.g., primary brain tumor, seizures not controlled with standard medical therapy, or history of stroke)
- •Inability to comply with study and/or follow-up procedures
- •History of other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that might affect the interpretation of the results of the study or render the subject at high risk from treatment complications.
研究组 & 干预措施
Therapeutic Intervention
Experimental
Tarceva and Avastin:
- Tarceva: 150mg PO, days 1-28
- Avastin: 10mg/kg, IV infusion, days 1,15 Regimen will be repeated every 28 days = 1 course
干预措施: bevacizumab (Biological)
Therapeutic Intervention
Experimental
Tarceva and Avastin:
- Tarceva: 150mg PO, days 1-28
- Avastin: 10mg/kg, IV infusion, days 1,15 Regimen will be repeated every 28 days = 1 course
干预措施: erlotinib hydrochloride (Drug)
Therapeutic Intervention
Experimental
Tarceva and Avastin:
- Tarceva: 150mg PO, days 1-28
- Avastin: 10mg/kg, IV infusion, days 1,15 Regimen will be repeated every 28 days = 1 course
干预措施: fluorescence in situ hybridization (Genetic)
Therapeutic Intervention
Experimental
Tarceva and Avastin:
- Tarceva: 150mg PO, days 1-28
- Avastin: 10mg/kg, IV infusion, days 1,15 Regimen will be repeated every 28 days = 1 course
干预措施: gene expression analysis (Genetic)
Therapeutic Intervention
Experimental
Tarceva and Avastin:
- Tarceva: 150mg PO, days 1-28
- Avastin: 10mg/kg, IV infusion, days 1,15 Regimen will be repeated every 28 days = 1 course
干预措施: immunologic technique (Other)
Therapeutic Intervention
Experimental
Tarceva and Avastin:
- Tarceva: 150mg PO, days 1-28
- Avastin: 10mg/kg, IV infusion, days 1,15 Regimen will be repeated every 28 days = 1 course
干预措施: laboratory biomarker analysis (Other)
Therapeutic Intervention
Experimental
Tarceva and Avastin:
- Tarceva: 150mg PO, days 1-28
- Avastin: 10mg/kg, IV infusion, days 1,15 Regimen will be repeated every 28 days = 1 course
干预措施: biopsy (Procedure)
结局指标
主要结局
Number of Patients With Response
时间窗: At 6 months
Per Response Evaluation Criteria in Solid Tumor (RECIST): Progressive disease (PD): \>=20% increase in sum of longest diameter (LD) of target lesion(s), taking as reference smallest sum LD recorded since treatment started. Complete response (CR): disappearance of all target lesions. Partial response (PR): \>=30% decrease in sum of LD of target lesion(s), taking as reference baseline sum LD. Stable disease (SD): neither sufficient shrinkage to qualify as PR nor sufficient increase to qualify as PD.
次要结局
- Time to Disease Progression.(up to one year after off-study date)
- Progression-free Survival at 6 Months(6 months)
- Number of Patients With Each Worst-grade Toxicity Response(Day 1 of each 28-day cycle for 6 cycles (168 days))
研究者
Jeffrey A. Sosman, MD
Professor of Medicine; Director, Melanoma and Tumor Immunotherapy
Vanderbilt-Ingram Cancer Center
研究点 (4)
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