The relationship between cortical activity and cognitive function after traumatic brain injury

Not Applicable

Completed

• Conditions: Traumatic Brain Injury (TBI); Injuries and Accidents - Other injuries and accidents

• Registration Number: ACTRN12616001038482
• Lead Sponsor: A/Prof Kate Hoy

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-08-04
• Study Completion: 2019-08-26
• Last Update Posted: 16 February 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

Inclusion Criteria for mTBI
1. Are voluntary and competent to consent,
2. Are right handed,
3. Are between the ages of 18 and 55 years,
4. Sustained a traumatic brain injury (mild to moderate: Glasgow Coma Scale 9>15)

Inclusion Criteria for controls
1. Are voluntary and competent to consent,
2. Are right handed,
3. Are between the ages of 18 and 55 years,
4. No history of head injury

Exclusion Criteria

General Exclusion Criteria
1.Are pregnant or lactating
2.History of neurological or mental illness
3.Have a DSM-IV history of substance abuse or dependence in the last 6 months
4.Taking medication known to alter brain excitability, plasticity
5.History of seizures
6.Have metal anywhere in the head, except the mouth. This includes metallic objects such as screws, plates and clips from surgical procedures.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
TMS-EEG data.<br>TMS-EEG is performed by stimulating the scalp over the DLPFC while simultaneously recording brain activity via surrounding EEG electrodes. The TMS pulse produces a neurophysiological response in the underlying cortex, referred to as the TMS evoked potential (TEP), which is recorded on EEG and the TEP amplitude gives an index of cortical excitability.[Baseline, 3 months and 6 months post head injury.]

Secondary Outcome Measures

Name	Time	Method
europsychological Assessment Battery assessing the domains of speed of processing, attention, verbal learning, working memory, visual learning, reasoning, and problem solving.<br><br>This is a composite outcome measure.[Baseline, 3 months and 6 months post head injury.];Working memory performance: computerised n-back memory task (accuracy and reaction time)[Baseline, 3 months and 6 months post head injury.]