Functional connectivity of cortico-cortical and subcortico-cortical brain networks in Parkinson*s disease
Completed
- Conditions
- parkinsonismParkinson's Disease10028037
- Registration Number
- NL-OMON39613
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
idiopathic PD, 40-65yo
Exclusion Criteria
psychotropic medication
epilepsy
metal in body
pregnancy
other neurological disease
major somatic disorders
severe claustrophobia
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Blood oxygenation level dependent (BOLD) response in dorsal frontal-striatal<br /><br>and cortico-cortical systems in PD patients and controls, compared to their<br /><br>BOLD response as measured during the initial testing session.</p><br>
- Secondary Outcome Measures
Name Time Method <p>secundary study parameters:<br /><br>1) Differences in BOLD responses across differnet cognitive and psychiatric<br /><br>symptom-related subgroups in PD patients.<br /><br><br /><br>2) Structural abnormalities in PD versus controls, using:<br /><br>a) voxel-based morphometry (VBM): measure for regional volumetry<br /><br>b) diffusion tensor imaging (DTI): measure for structural connectivity<br /><br><br /><br>3) Resting state functional connectivity in PD versus controls, focussing on:<br /><br>a) cortico-cortical connections<br /><br>b) cortico-subcortical connections<br /><br><br /><br>4) Differences in functional and structural measures between the initial and<br /><br>the current testing session</p><br>