Efficacy and safety of Praziquantel alone or in combination with Artemisinin-based combinations in the treatment of children with Schistosoma mansoni in Mwea, Kirinyaga County, Kenya

Kenya Medical Research Institute0 个研究点目标入组 540 人开始时间: 2019年12月7日最近更新: 2023年5月29日

适应症

试验速览

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•For participants to be enrolled in the study they have to meet ALL of the following criteria:
•Aged between 6 and 15 years old (confirmed from the date of birth recorded on the school registers),
•Testing positive for S. mansoni infection (confirmed by presence of eggs in stool).
•Residing in Mwea East and Mwea West, Kirinyaga County
•Able to take oral treatment
•Respective parent/ guardian provides written informed consent for the child to participate in the study
•Child provides written assent to participate in the study

•Potential participants will be excluded for any of the following reasons:
•Weighing more than 50 kg,
•Haemoglobin level = 5.0g/dL
•Signs of severe malnutrition (defined as severe wasting or MUAC <12cm)
•Hypersensitivity to Artesunates, sulfonamides or praziquantel.
•Use of an anti-malaria or anti-schistosomial drug within 28 days before enrollment in the study.

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