Efficacy and Safety of Praziquantel combined with Dihydroartemisinin-Piperaquine for the treatment of schistosomiasis; Pharmacokinetics and Pharmacogenetics implications of the drugs combination in Tanzania

Muhumbili University of Health and Allied Sciences0 个研究点目标入组 600 人开始时间: 2016年12月7日最近更新: 2023年5月29日

适应症

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•1. School children aged 5-15 years, both male and females 2. Live primarily in a study village/area. 3. School children confirmed schistosomiasis positive by urine filtration test for urinary schistosomiasis and kato-katz for intestinal schistosomiasis 4. School children confirmed malaria positive or negative by microscopy 5.Parent/s has/have consented for child to recruited in this study 6. The child has assented to participate 7. No Known or documented sensitivity to any of the drugs under test

•1. Patients without diagnosis of Schistosomiasis (tested negative for schistosomiasis) 2.A recent PZQ treatment before entry to the study(2 months) 3. Presence of danger signs and symptoms of severe malaria according to WHO criteria 4. Prior treatment of malaria within 14 days of study enrollement 5. Patient receiving any medication known to affect cytochrome P450 within 14 days of the study enrollement 6. Pregnant women

发起方

Muhumbili University of Health and Allied Sciences