The role of low frequency stimulation of the mesiotemporal region in memory enhancement
Phase 1
Recruiting
- Conditions
- Dystonia
- Registration Number
- DRKS00024072
- Lead Sponsor
- niversitätsklinik für Neurologie, Evangelisches Krankenhaus Oldenburg Abteilung für Neurologie, Fakultät für Medizin und Gesundheitswissenschaften, Carl von Ossietzky Universität Oldenburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 7
Inclusion Criteria
Dystonia patients will be included, if they have received DBS in the GPi, if they match the age range of 35-65 years and if they are female. Further, a pre-operative MRI or CT is required to locate the placement of electrodes using lead DBS.
Exclusion Criteria
Patients will be excluded from the study, if thy show any kind of cognitive impairment and/or if the electrode was not correctly placed in the GPi, according to LeadDBS.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The goal of this study is to provide a control group for already existing and also ethically approved data. To see whether the results can be replicated by stimulating correctly placed electrodes of the GPi, comparable cases need to be provided. The proposed study is considered purely experimental and is not aimed to give any therapeutic insight. <br><br>Cognitive Performance is measured using four neuropsychological tests: Word-Pair learning, Digit ordering, stroop task and verbal fluency. All tests are done on three days under different stimulation conditions (no stimulation, 20Hz and 120 Hz Stimulation).
- Secondary Outcome Measures
Name Time Method Secondary outcome are neurological examination and a wellbeing questionnaire.