Catch the cancer; towards a cfDNA-based test for colorectal cancer screening
- Conditions
- <p>Lynch syndrome, colorectal cancer</p>
- Registration Number
- NL-OMON29451
- Lead Sponsor
- Erasmus MC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 150
Lynch syndrome carriers (of at least 18 years of age) being under surveillance in our centre that granted informed consent to participate in our study OR participants from the national CRC screening program with a positive FIT that granted informed consent to participate in our study.
Individuals participating in the Dutch national CRC screening program who are known to be carrier of a genetic predisposition for CRC (for example Familial Adenomatous Polyposis or MUTYH Associated Polyposis), or have a negative FIT, or have a positive FIT with sequential colonoscopy already performed, or are unwilling to undergo colonoscopy or to receive unexpected, but relevant and actionable findings, or underwent a failed colonoscopy; and LS carriers who are unwilling to undergo colonoscopy or to receive unexpected, but relevant and actionable findings, who are <18 years, who underwent a failed colonoscopy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The agreement between cfDNA profiles and DNA profiles of corresponding lesions (advanced adenomas, CRC)</p>
- Secondary Outcome Measures
Name Time Method <p>The psychological impact of this cfDNA-based blood test.</p>