Impact of Draining Significant Effusion on Gas Exchange and Lung Mechanics in Patient Under Mechanical Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 主要终点
- Correlation between estimated and drained effusion volume
研究概览
简要总结
Patients with acute respiratory failure (ARF) who were receiving mechanical ventilator support, had significant pleural effusion (both transudates and exudates) and drainage plan were evaluated. Decision to drain, timing and duration of drainage were made by primary physician according to the intensive care unit (ICU) protocols.The estimated amount of effusion (mL) was calculated as the maximum pleura-lung distance (mm) x 20 and significant effusion is accepted as ≥ 800 mL according to thoracic ultrasonography (USG) performed by the intensivist. The amount of effusion drained, mechanical ventilator parameters, arterial blood gas results and hemodynamic data were recorded before, at the 1st hour and at the end of drainage up to 30 days after drainage.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients on mechanical ventilation due to acute respiratory failure
- •Estimated effusion > 800 ml according to USG
- •Have drainage plan according to ICU protocols decided by primary physician
排除标准
- •Have absolute drainage indication (empyema, hemothorax or chylothorax)
- •predicted duration of mechanical ventilation less than 72 hours
- •contraindications to drainage,
- •underlying disease, which prevents lung expansion (chest deformity, central atelectasis)
- •malignant effusions
结局指标
主要结局
Correlation between estimated and drained effusion volume
时间窗: 1- Estimated effusion volume just before the drainage (by ultrasonography calculated as described in brief summary) 2- Drained effusion volume just after the drainage is terminated up to 30 days after procedure.
Volume of the effusion estimated and drained was recorded (mL)
Change in Lung mechanics
时间窗: 1- Dynamic Compliance just before the drainage 2- Dynamic Compliance just after the drainage is terminated up to 30 days after procedure
Dynamic Compliance (mL/cmH2O)
Change in Oxygenation
时间窗: 1- PaO2/FiO2 just before the drainage 2- PaO2/FiO2 just after the drainage is terminated up to 30 days after procedure
PaO2/FiO2 (fraction of inspired oxygen)
次要结局
未报告次要终点
研究者
Begum Ergan
Staff pulmonologist and intensivist in Department Pulmonary and Critical Care Medicine in Dokuz Eylul Universty Hospital, Dokuz Eylul University
Dokuz Eylul University