Impact of Draining Significant Effusion on Gas Exchange and Lung Mechanics in Patient Under Mechanical Ventilation

Completed

• Conditions: Respiration, Artificial; Ultrasonography; Pleural Effusion
• Interventions: Procedure: Drainage of the pleural effusion

• Registration Number: NCT03394872
• Lead Sponsor: Dokuz Eylul University

Brief Summary

Patients with acute respiratory failure (ARF) who were receiving mechanical ventilator support, had significant pleural effusion (both transudates and exudates) and drainage plan were evaluated. Decision to drain, timing and duration of drainage were made by primary physician according to the intensive care unit (ICU) protocols.The estimated amount of effusion (mL) was calculated as the maximum pleura-lung distance (mm) x 20 and significant effusion is accepted as ≥ 800 mL according to thoracic ultrasonography (USG) performed by the intensivist. The amount of effusion drained, mechanical ventilator parameters, arterial blood gas results and hemodynamic data were recorded before, at the 1st hour and at the end of drainage up to 30 days after drainage.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-05-01
• Primary Completion: 2017-08-30
• Study Completion: 2017-08-30
• Study First Submitted: 2017-12-19
• Status Verified: 2018-01
• Study First Submitted QC: 2018-01-08
• Last Update Submitted: 2018-01-08
• Study First Posted: 2018-01-09
• Last Update Posted: 2018-01-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

• Patients on mechanical ventilation due to acute respiratory failure
• Estimated effusion > 800 ml according to USG
• Have drainage plan according to ICU protocols decided by primary physician

Exclusion Criteria

• Have absolute drainage indication (empyema, hemothorax or chylothorax)
• predicted duration of mechanical ventilation less than 72 hours
• contraindications to drainage,
• underlying disease, which prevents lung expansion (chest deformity, central atelectasis)
• malignant effusions

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Drainage group	Drainage of the pleural effusion	Patients under mechanical ventilator support due to acute respiratory failure who had significant pleural effusion and drainage plan according to the intensive Care Unit (ICU) protocols decided by primary physician

Primary Outcome Measures

Name	Time	Method
Correlation between estimated and drained effusion volume	1- Estimated effusion volume just before the drainage (by ultrasonography calculated as described in brief summary) 2- Drained effusion volume just after the drainage is terminated up to 30 days after procedure.	Volume of the effusion estimated and drained was recorded (mL)
Change in Lung mechanics	1- Dynamic Compliance just before the drainage 2- Dynamic Compliance just after the drainage is terminated up to 30 days after procedure	Dynamic Compliance (mL/cmH2O)
Change in Oxygenation	1- PaO2/FiO2 just before the drainage 2- PaO2/FiO2 just after the drainage is terminated up to 30 days after procedure	PaO2/FiO2 (fraction of inspired oxygen)