Clinical and Genetic Characteristics of Coronary Artery Disease in Chinese Young Adults
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Coronary Artery Disease
- Sponsor
- Shanghai Zhongshan Hospital
- Enrollment
- 2000
- Locations
- 38
- Primary Endpoint
- Number of participants undergoing unscheduled repeat revascularization of target or non-target vessel
- Last Updated
- 7 years ago
Overview
Brief Summary
The aim of this study is to identify genetic loci,or gene variations contributing to the development of coronary artery disease (CAD) in Chinese young adults. Investigators will compare coronary angiogram results to genetic findings within young CAD patients.
Detailed Description
During last 10 years, the rise in coronary artery disease (CAD) prevalence in Chinese young adults is observed and percutaneous coronary intervention (PCI) is generally considered to be low operative risk in these young patients. Genome-wide association studies have identified a considerable number of common genetic variants related to CAD. However, the extent to which these genetic variants are related to the future cardiovascular events, the prevalence, extent, severity, and prognosis of young patients with CAD is not clear. The aim of this study is to investigate the genetic loci, or gene variations contributing to the development and prognosis of CAD in Chinese young adult. Investigators will compare the angiogram results to genetic findings first in patients with different stages of CAD. Then, investigators will collect patients from hospital discharge registry, and compare long-term outcome as well as on operative details in different gene groups. The results of the study provide a possibility to develop a gene test to recognize patients at risk at its early stage, and needing for preventive medicine.
Investigators
Junbo Ge
Dr.
Shanghai Zhongshan Hospital
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Number of participants undergoing unscheduled repeat revascularization of target or non-target vessel
Time Frame: 36 months
Any unshceduled percutaneous coronary intervention or coronary artery bypass grafting after primary revascularization
Number of patients developing stroke
Time Frame: 36 months
Any events of ishcemic stroke, TIA or hemorrhagic stroke
Number of cardiac death
Time Frame: 36 months
Any death from cardiac conditions
Number of patients developing myocardial infarction
Time Frame: 36 months
Any case of acute myocardial infarction which meet the Criteria according to current guidelines.
Secondary Outcomes
- Number of stent thrombosis, bleeding、non-cardiac death and all-cause death.(36 months)