Clinical and Genetic Characteristics of Coronary Artery Disease in Chinese Young Adults
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 2,000
- 试验地点
- 38
- 主要终点
- Number of participants undergoing unscheduled repeat revascularization of target or non-target vessel
研究概览
简要总结
The aim of this study is to identify genetic loci,or gene variations contributing to the development of coronary artery disease (CAD) in Chinese young adults. Investigators will compare coronary angiogram results to genetic findings within young CAD patients.
详细描述
During last 10 years, the rise in coronary artery disease (CAD) prevalence in Chinese young adults is observed and percutaneous coronary intervention (PCI) is generally considered to be low operative risk in these young patients. Genome-wide association studies have identified a considerable number of common genetic variants related to CAD. However, the extent to which these genetic variants are related to the future cardiovascular events, the prevalence, extent, severity, and prognosis of young patients with CAD is not clear.
The aim of this study is to investigate the genetic loci, or gene variations contributing to the development and prognosis of CAD in Chinese young adult. Investigators will compare the angiogram results to genetic findings first in patients with different stages of CAD. Then, investigators will collect patients from hospital discharge registry, and compare long-term outcome as well as on operative details in different gene groups.
The results of the study provide a possibility to develop a gene test to recognize patients at risk at its early stage, and needing for preventive medicine.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Number of participants undergoing unscheduled repeat revascularization of target or non-target vessel
时间窗: 36 months
Any unshceduled percutaneous coronary intervention or coronary artery bypass grafting after primary revascularization
Number of patients developing stroke
时间窗: 36 months
Any events of ishcemic stroke, TIA or hemorrhagic stroke
Number of cardiac death
时间窗: 36 months
Any death from cardiac conditions
Number of patients developing myocardial infarction
时间窗: 36 months
Any case of acute myocardial infarction which meet the Criteria according to current guidelines.
次要结局
- Number of stent thrombosis, bleeding、non-cardiac death and all-cause death.(36 months)
研究者
Junbo Ge
Dr.
Shanghai Zhongshan Hospital