Clinical and Genetic Characteristics of Coronary Artery Disease in Chinese Young Adults

• Conditions: Percutaneous Coronary Intervention; Coronary Artery Disease

• Registration Number: NCT02496858
• Lead Sponsor: Shanghai Zhongshan Hospital

Brief Summary

The aim of this study is to identify genetic loci,or gene variations contributing to the development of coronary artery disease (CAD) in Chinese young adults. Investigators will compare coronary angiogram results to genetic findings within young CAD patients.

Detailed Description

During last 10 years, the rise in coronary artery disease (CAD) prevalence in Chinese young adults is observed and percutaneous coronary intervention (PCI) is generally considered to be low operative risk in these young patients. Genome-wide association studies have identified a considerable number of common genetic variants related to CAD. However, the extent to which these genetic variants are related to the future cardiovascular events, the prevalence, extent, severity, and prognosis of young patients with CAD is not clear.

The aim of this study is to investigate the genetic loci, or gene variations contributing to the development and prognosis of CAD in Chinese young adult. Investigators will compare the angiogram results to genetic findings first in patients with different stages of CAD. Then, investigators will collect patients from hospital discharge registry, and compare long-term outcome as well as on operative details in different gene groups.

The results of the study provide a possibility to develop a gene test to recognize patients at risk at its early stage, and needing for preventive medicine.

Study Timeline

• Study First Submitted: 2015-07-07
• Study First Submitted QC: 2015-07-09
• Study First Posted: 2015-07-14
• Study Start: 2017-05-12
• Status Verified: 2019-02
• Last Update Submitted: 2019-02-20
• Last Update Posted: 2019-02-21
• Primary Completion: 2019-05
• Study Completion: 2022-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of participants undergoing unscheduled repeat revascularization of target or non-target vessel	36 months	Any unshceduled percutaneous coronary intervention or coronary artery bypass grafting after primary revascularization
Number of patients developing stroke	36 months	Any events of ishcemic stroke, TIA or hemorrhagic stroke
Number of cardiac death	36 months	Any death from cardiac conditions
Number of patients developing myocardial infarction	36 months	Any case of acute myocardial infarction which meet the Criteria according to current guidelines.

Secondary Outcome Measures

Name	Time	Method
Number of stent thrombosis, bleeding、non-cardiac death and all-cause death.	36 months	Composite of stent thrombosis, bleeding、non-cardiac death and all-cause death.

Trial Locations

Locations (38)

China-Japan Friendship Hospital; 🇨🇳 Beijing, Beijing, China

Xiamen Cardiovascular Hospital; 🇨🇳 Xiamen, Fujian, China

The First Hospital of Lanzhou University; 🇨🇳 Lanzhou, Gansu, China

Guangdong Provincial People's Hospital; 🇨🇳 Guangzhou, Guangdong, China

Sun yat-sen Memorial Hospital; 🇨🇳 Guangzhou, Guangdong, China

Zhuhai Hospital of Guangdong Provincial People's Hospital; 🇨🇳 Zhuhai, Guangdong, China

The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine; 🇨🇳 Nanning, Guangxi, China

Affiliated Hospital of Zunyi Medical College; 🇨🇳 Zunyi, Guizhou, China

The second Hospital of Hebei Medical University; 🇨🇳 Shijiazhuang, Hebei, China

Wuhan Asia Heart Hospital; 🇨🇳 Wuhan, Hubei, China

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