Clinical and Genetic Characteristics of Coronary Artery Disease in Chinese Young Adults
- Conditions
- Percutaneous Coronary InterventionCoronary Artery Disease
- Registration Number
- NCT02496858
- Lead Sponsor
- Shanghai Zhongshan Hospital
- Brief Summary
The aim of this study is to identify genetic loci,or gene variations contributing to the development of coronary artery disease (CAD) in Chinese young adults. Investigators will compare coronary angiogram results to genetic findings within young CAD patients.
- Detailed Description
During last 10 years, the rise in coronary artery disease (CAD) prevalence in Chinese young adults is observed and percutaneous coronary intervention (PCI) is generally considered to be low operative risk in these young patients. Genome-wide association studies have identified a considerable number of common genetic variants related to CAD. However, the extent to which these genetic variants are related to the future cardiovascular events, the prevalence, extent, severity, and prognosis of young patients with CAD is not clear.
The aim of this study is to investigate the genetic loci, or gene variations contributing to the development and prognosis of CAD in Chinese young adult. Investigators will compare the angiogram results to genetic findings first in patients with different stages of CAD. Then, investigators will collect patients from hospital discharge registry, and compare long-term outcome as well as on operative details in different gene groups.
The results of the study provide a possibility to develop a gene test to recognize patients at risk at its early stage, and needing for preventive medicine.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 2000
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Number of participants undergoing unscheduled repeat revascularization of target or non-target vessel 36 months Any unshceduled percutaneous coronary intervention or coronary artery bypass grafting after primary revascularization
Number of patients developing stroke 36 months Any events of ishcemic stroke, TIA or hemorrhagic stroke
Number of cardiac death 36 months Any death from cardiac conditions
Number of patients developing myocardial infarction 36 months Any case of acute myocardial infarction which meet the Criteria according to current guidelines.
- Secondary Outcome Measures
Name Time Method Number of stent thrombosis, bleeding、non-cardiac death and all-cause death. 36 months Composite of stent thrombosis, bleeding、non-cardiac death and all-cause death.
Trial Locations
- Locations (38)
Xuzhou Fourth People's Hospital
🇨🇳Xuzhou, Jiangsu, China
Affiliated Hospital of Zunyi Medical College
🇨🇳Zunyi, Guizhou, China
China-Japan Friendship Hospital
🇨🇳Beijing, Beijing, China
Xiamen Cardiovascular Hospital
🇨🇳Xiamen, Fujian, China
The First Hospital of Lanzhou University
🇨🇳Lanzhou, Gansu, China
Zhuhai Hospital of Guangdong Provincial People's Hospital
🇨🇳Zhuhai, Guangdong, China
Wuhan Asia Heart Hospital
🇨🇳Wuhan, Hubei, China
Guangdong Provincial People's Hospital
🇨🇳Guangzhou, Guangdong, China
The second Hospital of Hebei Medical University
🇨🇳Shijiazhuang, Hebei, China
Sun yat-sen Memorial Hospital
🇨🇳Guangzhou, Guangdong, China
Shanghai Zhongshan Hospital
🇨🇳Shanghai, Shanghai, China
The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine
🇨🇳Nanning, Guangxi, China
Wuxi Third People's Hospital
🇨🇳Wuxi, Jiangsu, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
The second Hospital of Jilin University
🇨🇳Chang chun, Jilin, China
General Hospital of Ningxia Medical University
🇨🇳Yinchuan, Ningxia, China
The First Affiliated Hospital of Xi 'an Jiaotong University
🇨🇳Xi'an, Shaanxi, China
Central Hospital of Jiading District
🇨🇳Shanghai, Shanghai, China
Central Hospital of Minhang District
🇨🇳Shanghai, Shanghai, China
Central Hospital of Yangpu District
🇨🇳Shanghai, Shanghai, China
Yan'an Hospital of Kunming City
🇨🇳Kunming, Yunnan, China
Yueyang hospital
🇨🇳Shanghai, Shanghai, China
Changhai Hospital of Second Military Medical University of Chinese PLA
🇨🇳Shanghai, Shanghai, China
Shanghai Changzheng Hospital
🇨🇳Shanghai, Shanghai, China
Shanghai Tongren Hospital
🇨🇳Shanghai, Shanghai, China
Shanghai chest hospital
🇨🇳Shanghai, Shanghai, China
Taiyuan central hospital
🇨🇳Taiyuan, Shanxi, China
Shanghai Shidong Hospital
🇨🇳Shanghai, Shanghai, China
Tongji Hospital of Tongji University
🇨🇳Shanghai, Shanghai, China
Shanghai First People's Hospital
🇨🇳Shanghai, Shanghai, China
Zhenjiang First People's Hospital
🇨🇳Hangzhou, Zhenjiang, China
Shanghai Ninth People's Hospital
🇨🇳Shanghai, Shanghai, China
Shanghai Sixth People's Hospital
🇨🇳Shanghai, Shanghai, China
Shanxi cardiovascular hospital
🇨🇳Taiyuan, Shanxi, China
Tianjin Chest Hospital
🇨🇳Tianjin, Tianjin, China
Karamay Central Hospital
🇨🇳Karamay, Xinjiang, China
Tenth People's Hospital of Tongji University
🇨🇳Shanghai, Shanghai, China
Second Affiliated Hospital of Zhejiang University
🇨🇳Hangzhou, Zhejiang, China