Congenital Heart Disease GEnetic NEtwork Study (CHD GENES)
- Conditions
- Congenital Heart Defects
- Registration Number
- NCT01196182
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Brief Summary
Congenital heart defects (CHD) are the most common major human birth malformation, affecting \~8 per 1,000 live births. CHD are associated with significant morbidity and mortality, and are second only to infectious diseases in contributing to the infant mortality rate. Current understanding of the etiology of pediatric cardiovascular disorders is limited.
The Congenital Heart Disease GEnetic NEtwork Study (CHD GENES) is a multi-center, prospective observational cohort study. Participants will be recruited from the Pediatric Cardiac Genomics Consortium's (PCGC) centers of the NHLBI-sponsored Bench to Bassinet (B2B) Program. Biological specimens will be obtained for genetic analyses, and phenotype data will be collected by interview and from medical records. State-of-the-art genomic technologies will be used to identify common genetic causes of CHD and genetic modifiers of clinical outcome.
To accomplish this, the PCGC will develop and maintain a biorepository of specimens (DNA) and genetic data, along with detailed, phenotypic and clinical outcomes data in order to investigate relationships between genetic factors and phenotypic and clinical outcomes in congenital heart disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 10000
• Signed consent form
- Isolated patent foramen ovale
- Isolated prematurity-associated patent ductus arteriosus
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (13)
Columbia University Medical Center
🇺🇸New York, New York, United States
Cohen Children's Medical Center New York
🇺🇸New Hyde Park, New York, United States
Yale University
🇺🇸New Haven, Connecticut, United States
Stanford University
🇺🇸Palo Alto, California, United States
Mount Sinai School of Medicine
🇺🇸New York, New York, United States
Children's Hospital Boston
🇺🇸Boston, Massachusetts, United States
University of Rochester
🇺🇸Rochester, New York, United States
University of California, San Francisco
🇺🇸San Francisco, California, United States
Brigham & Women's Hospital
🇺🇸Boston, Massachusetts, United States
Children's Hospital Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
University of Utah
🇺🇸Salt Lake City, Utah, United States
University College London
🇬🇧London, United Kingdom
Children's Hospital Los Angeles
🇺🇸Los Angeles, California, United States