The effect of iontophoresis and surfactant on transdermal apomorphine micro-emulsion treatment in patients with Parkinson's Disease

Phase 2

• Conditions: Parkinson; parkinsonism; Parkinson's disease; 10028037

• Registration Number: NL-OMON30219
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 5

Inclusion Criteria

- Patients with parkinson's disease with at random fluctuations that are insufficiently medicated with oral parkinson medication
-age > 18
-patient signed approved informed consent;-patient should be capable of understanding the protocol

Exclusion Criteria

- severe reaction on subcutaneous apomorphine test
-little skin pigmentation combined with burned skin
-instable internal pathology
-changes in parkinson medication during the past month
-Mini Mental State Examination <24
- Orthostatic hypotension

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Clinical improvement<br /><br>- tapping score<br /><br>- standard scales for clinical improvement<br /><br><br /><br>side-effects<br /><br>-scales<br /><br>-visual scoringsystem</p><br>

Secondary Outcome Measures

Name	Time	Method
<p> apomorphine plasma concentration </p><br>