Implementing Good Nutrition to Improve, Transform, and Enhance Firefighters' Health
Overview
- Phase
- N/A
- Intervention
- Whole Foods Plant-Based Diet
- Conditions
- Cancer
- Sponsor
- Stanford University
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- Difference in IL-6
- Status
- Active, Not Recruiting
- Last Updated
- 3 months ago
Overview
Brief Summary
Investigators hope to learn about potential dietary intervention strategies (specifically a whole-food, plant-based diet) that may help lower cancer markers in firefighters.
Detailed Description
The purpose of the San Francisco (SF) Firefighter's Diet Study is to determine if a diet low in processed foods, mostly plant-based, with added fermented foods, can lower the risk of cancer in firefighters. We will assess this by randomly assigning SF firefighters to either a whole-food, plant-based diet or their usual firehouse meals. Participants will be followed for 12 weeks.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Active SF firefighter
- •Willing to consume a plant-based diet (vegetables, fruit, whole grains, legumes, etc.)
- •Willing to complete 4 clinic visits
Exclusion Criteria
- •Weight \< 110 lb
- •BMI \>= 40
- •Self-reported uncontrolled hypercholesterolemia, hypertension or diabetes
- •Pregnant, lactating, or planning to become pregnant during the course of the study.
- •Use of any of the following drugs/supplements within the last 2 months:
- •systemic antibiotics, antifungals, antivirals, or antiparasitics (intravenous, intramuscular, or oral);
- •corticosteroids (intravenous, intramuscular, oral, nasal or inhaled);
- •cytokines;
- •methotrexate or immunosuppressive cytotoxic agents.
- •Chronic, clinically significant, or unstable (unresolved, requiring ongoing changes to medical management or medication) pulmonary, cardiovascular, gastrointestinal, hepatic or renal functional abnormality, as determined by medical history, Type 1 diabetes, dialysis
Arms & Interventions
Whole Food Plant-Based Diet
Participants will be asked to consume and predominantly vegan, whole-foods diet, with the addition of fish, eggs, and fermented dairy.
Intervention: Whole Foods Plant-Based Diet
Usual Firehouse Diet
Participants will be asked to consume their usual firehouse meals.
Intervention: Usual Firehouse Diet
Outcomes
Primary Outcomes
Difference in IL-6
Time Frame: Baseline and 8 weeks
Difference in the 8-week change from baseline in IL-6 between the whole-food plant-based vs. usual diet groups.
Secondary Outcomes
- Difference in Protein Carbonyl (protein oxidation)(Baseline and 8 weeks)
- Difference in Glyc a(Baseline and 8 weeks)
- Difference in C-Reactive Protein (CRP)(Baseline and 8 weeks)
- Difference in Interleukin-10 (L-10)(Baseline and 8 weeks)
- Difference in Tumor Necrosis Factor-alpha (TNF-alpha)(Baseline and 8 weeks)
- Difference in Cytokines and Inflammatory Proteins(Baseline and 8 weeks)
- Difference in Calprotectin(Baseline and 8 weeks)
- Difference in 8-hydroxy-2'-deoxyguanosine (8-OH-dG)(Baseline and 8 weeks)
- Difference in Lipid Peroxidation(Baseline and 8 weeks)
- Difference in Fasting Glucose(Baseline and 8 weeks)
- Difference in Fasting Insulin(Baseline and 8 weeks)
- Difference in Low-Density-Lipoprotein Cholesterol (LDL)(Baseline and 8 weeks)
- Difference in High-Density-Lipoprotein Cholesterol (HDL)(Baseline and 8 weeks)
- Difference in Triglycerides (TRGs)(Baseline and 8 weeks)
- Difference in Telomeres(Baseline and 8 weeks)
- Difference in Epigenetic Age(Baseline and 8 weeks)
- Difference in Gut Microbiome Composition(Baseline and 8 weeks)
- Difference in Metabolomic Profiles(Baseline and 8 weeks)
- Difference in 4-hydroxynonenal (HNE)(Baseline and 8 weeks)
- Difference in body composition(Baseline and 8 weeks)
- Difference in weight(Baseline and 8 weeks)
- Difference in systolic blood pressure(Baseline and 8 weeks)
- Difference in diastolic blood pressure(Baseline and 8 weeks)