Comparison of Drugs, Fluvoxamine and Fluoxetine in patients with OCD in terms of efficacy and effect on clinical and biochemical parameters.
Not Applicable
- Conditions
- Health Condition 1: F42- Obsessive-compulsive disorder
- Registration Number
- CTRI/2023/01/048722
- Lead Sponsor
- Government Medical College and Hospital, Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Diagnosis of OCD as per ICD 11
2.Drug naïve patients and patients not on medication from last 4 weeks.
3.Those consenting to participate
4.Age group 18 to 55 years
5.Any gender
Exclusion Criteria
1.Depression and anxiety disorder of diagnosable severity .
2.Co morbid diagnosed cases of Huntington, Alzheimer, Parkinson s disease ,cancer, sepsis or history of chronic infection.
3.Patients with co morbid substance dependence (except nicotine and caffeine) .
4.Patients diagnosed with any unstable medical, surgical illness (kidney disease, liver disease, chronic heart disease , thyroid disfunction, myasthenia gravis).
5.Pregnant and lactating women.
6.Actively suicidal patients.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To estimate the levels of BDNF , Malondialdehyde , ESR, CRP, Procalcitonin and to corelate these with the severity of OCD. <br/ ><br>2.To assess early response of fluvoxamine and fluoxetine in OCD and their effect on levels of BDNF, MDA, ESR, CRP, PCT and Quality of Life (QoL) at 4 weeks . <br/ ><br>Timepoint: Baseline, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 12 weeks
- Secondary Outcome Measures
Name Time Method 1.To compare response with Fluvoxamine and Fluoxetine in relation to clinical and biochemical profile and QoL of patients with OCD at the end of 12 weeks.Timepoint: Baseline, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 12 weeks