The Role of Corticosteroids and Vestibular Exercises in Recovery of Vestibular Neuritis

Early Phase 1

• Conditions: Vestibular Neuritis
• Interventions: Drug: Corticosteroids; Other: Vestibular exercises

• Registration Number: NCT01231009
• Lead Sponsor: Aristotle University Of Thessaloniki

Brief Summary

Aim of present study is to determine whether corticosteroids and vestibular exercises are equal effective in the recovery of balance in patients with acute vestibular neuritis.

Detailed Description

Not available

Study Timeline

• Status Verified: 2010-01
• Study Start: 2010-01
• Study First Submitted: 2010-10-29
• Study First Submitted QC: 2010-10-29
• Last Update Submitted: 2010-10-29
• Study First Posted: 2010-11-01
• Last Update Posted: 2010-11-01
• Primary Completion: 2012-01
• Study Completion: 2013-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients with history of acute or sub-acute rotatory vertigo with postural imbalance, nausea and imbalance.
• Horizontal-rotatory spontaneous nystagmus.

Exclusion Criteria

• History of vestibular disfunction before the acute onset of symptoms
• Simultaneous Hearing loss
• Neurologic disorder
• Pregnancy or lactation
• History of psychiatric disorders
• History of glaucoma
• Diabetes
• Hypertension
• Contraindication in receiving corticosteroids

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Corticosteroids	Corticosteroids	Patients receive for 7 days intravenous corticosteroids, dexamethasone, and they continue receiving for 7 days corticosteroids per os
Corticosteroids	Vestibular exercises	Patients receive for 7 days intravenous corticosteroids, dexamethasone, and they continue receiving for 7 days corticosteroids per os
Vestibular exercises	Corticosteroids	Patients perform for 15 days certain vestibular exercises under suspicion of an expert physiotherapist
Vestibular exercises	Vestibular exercises	Patients perform for 15 days certain vestibular exercises under suspicion of an expert physiotherapist

Primary Outcome Measures

Name	Time	Method
clinical recovery of vestibular function	1 year	clinical examination (nystagmus, Romberg test, head-thrust test, head-shaking test) and questionnaires (Greek edition of Dizziness Handicap Inventory and European Evaluation of Vertigo Scale)
Laboratory recovery of vestibular	1 year	caloric test and vestibular evoked myogenic potentials

Trial Locations

Locations (1)

1st ENT Department, AHEPA University Hospital; 🇬🇷 Thessaloniki, Greece