The Efficacy of Steroid Therapy in Vestibular Neuritis Confirmed by Head Impulse Test: Prospective Randomized Controlled Study
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- The improvement in vestibular function test (caloric & videop HIT) after treatment
研究概览
简要总结
The purpose of this study was to compare the treatment effectiveness of steroid therapy for vestibular neuritis by using video head impulse test.
详细描述
This study was a prospective, randomized controlled study. The enrolled vestibular neuritis patients were randomized to conservative treatment or steroid treatment when they are diagnosed with caloric test. After initial vestibular work-up including caloric, video head impulse tests, and a questinnaire (DHI), the patient was examined with the same tests again at 6 months later. The efficacy of steroid for the patients with vestibular neuritis would be determined by the comparison of the data of each group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ages over 18 years
- •Acute vertigo that occurred within 7 days
- •The spontaneous nystagmus should be detected
- •Caloric weakness over 20%
排除标准
- •Suspicious or verified a central nervous system lesion
- •If the patient has denied.
- •Other otologic disease (acute/chronic otitis media, otosclerosis, etc)
- •The patient with history of otologic surgery
- •The patient with history of brain surgery
研究组 & 干预措施
: Ginkgo biloba & methylprednisolone
Patients receive Ginkgo biloba & methylprednisolone per oral.
干预措施: Ginkgo biloba & Methylprednisolone (Drug)
Ginkgo biloba
Patients receive Ginkgo biloba per oral.
干预措施: Ginkgo biloba (Drug)
结局指标
主要结局
The improvement in vestibular function test (caloric & videop HIT) after treatment
时间窗: The first results were collected at initial diagnosis. And following results were collected 6 months after the first exam.
The effectiveness of steroid therapy was determined by comparing the improvement of vestibular function (the degree of canal paresis by caloric test; gain and presence of refixation-saccade by video HIT test).
次要结局
- The improvement in dizziness handicap inventory after treatment(The first results were collected at initial diagnosis. And following results were collected 6 months after the first exam.)
研究者
Hong Ju Park
Professor
Asan Medical Center