Changes in gut bacteria and inflammation after performing exercise in Non-Alcoholic Fatty Liver Disease (NAFLD) patients

Not Applicable

• Conditions: on-alcoholic fatty liver disease; Gut microbiome diversity; Overweight; Obesity; Health related quality of life; Chronic inflammation; Non-alcoholic fatty liver disease; Metabolic and Endocrine - Metabolic disorders; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation

• Registration Number: ACTRN12623001018606
• Lead Sponsor: Mr Christiaan Hattingh

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-09-20
• Last Update Posted: 26 September 2023

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

(i)A diagnosis of NAFLD
(ii)No other liver disease or cancer present
(iii)Other well-managed comorbidities, e.g. Type 2 Diabetes Mellitus (T2DM), and hypertension, are approved for the study
(iv)No recent or current exercise performed
(v)Commit to the cross-sectional study and assess for the longitudinal study
(vi)Complete consent form

Exclusion Criteria

(i) Younger than 18 years of age
(ii) Serious cardiovascular, respiratory, or neurological diseases and cancers
(iii) Poorly controlled hypertension, glucose regulation or other serious chronic diseases
(iv) A disability that could prevent the completion of exercises
(v) High-risk participants with contraindications to exercise
(vi) Currently exercising more than 60 minutes per week
(vii) Participation in conflicting studies
(viii) Participants with internal artefacts that may obscure DXA readings
(ix) Participants who are pregnant, attempting to conceive or lactating.
(x) Participants exposed to radiation levels deemed unsafe in the DXA pre-testing preparation checklist.
(xi) Participants who cannot complete the 1RM and VO2max protocols.
(xii) Medications that could alter outcome measures

Study & Design

• Study Type: Interventional
• Study Design: Not specified