Effects of a physical exercise program on cardiac function of patients with Heart Failure

Not Applicable

Recruiting

• Conditions: Heart Failure; C14.280.434

• Registration Number: RBR-6djxqz
• Lead Sponsor: Hospital das Clínicas da Faculdade de Medicina de Botucatu

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-01-15
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Will be included participants older than 18 years; both sexes; heart failure with reduced ejection fraction (HFrEF) of various etiologies and optimized drug therapy.

Exclusion Criteria

Patients with heart failure grade III and IV and stage D; Hypertrophic cardiomyopathy; Deposit diseases; Mitral and aortic stenosis; Decompensated heart failure in the last three months; Persistent or permanent atrial fibrillation and/or artificial pacemaker rhythm; Chronic obstructive pulmonary disease; Biomechanical limitations that prevent them from participating in the proposed combined physical exercise program.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
a) Echocardiographic cardiac evaluation: 20% improvement of left ventricular diastolic and systolic function;<br><br>;b) Evaluation of circulating miRNAs: assess the profile as biomarkers to monitor the treatment of heart failure;<br>;c) Evaluation of plasma BNP concentration: 30% reduction after intervention;<br>;d) Evaluation of plasma nitrite / nitrate concentration: 30% increase after intervention.<br>

Secondary Outcome Measures

Name	Time	Method
a) Evaluation of inflammatory cytokines: improvement of inflammatory response in the range of 30 to 50% after the intervention;<br><br>;b) Handgrip assessment: increase after intervention;;c) Assessment of functional capacity: improvement at or above 300 meters in the Cooper Walking or Running Test 12 minutes the following week after 16 weeks of intervention;;d) Quality of life assessment: 15% improvement in perception on the quality of life scale after the intervention;;e) Bioimpedance assessment: improvement in the range of 5 to 10% of the total body fat index after the intervention.