A Phase I/II Study of the Histone Deacetylase (HDAC) Inhibitor LBH589 (Panobinostat) in Combination With mTOR Inhibitor RAD001 (Everolimus) in Patients With Relapsed Multiple Myeloma or Lymphoma
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 124
- 试验地点
- 3
- 主要终点
- Number of Phase I Participants With Dose-Limiting Toxicity Events (Phase I)
研究概览
简要总结
This phase I/II trial studies the side effects and best dose of panobinostat and everolimus when given together and to see how well they work in treating patients with multiple myeloma, non-Hodgkin lymphoma, or Hodgkin lymphoma that has come back. Panobinostat and everolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
详细描述
PRIMARY OBJECTIVES:
I. To determine the maximum tolerated doses (MTD) of LBH589 (panobinostat) and RAD001 (everolimus) when used in combination in patients with myeloma or lymphoma. (Phase I) II. To evaluate the therapeutic activity of the combination of LBH589 with RAD001 in patients with relapsed or refractory lymphoma. (Arm A, phase II) III. To evaluate the therapeutic activity of the combination of LBH589 with RAD001 in patients with relapsed or refractory multiple myeloma. (Arm B, phase II)
SECONDARY OBJECTIVES:
I. To describe the toxicities associated with the combination of LBH589 with RAD001. (Phase I) II. To further describe the toxicities associated with the combination of LBH589 with RAD001 in each arm independently. (Phase II) III. To evaluate overall survival, progression-free survival, and duration of response in each arm independently. (Phase II)
TERTIARY OBJECTIVES:
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Relapsed or refractory multiple myeloma requiring therapy, who have failed, unable to tolerate, or refused other available active therapies
- •Biopsy-proven relapsed or refractory non-Hodgkin lymphoma or Hodgkin disease requiring treatment, who have failed, unable to tolerate, or refused other available active therapies; patients should not have other treatment options considered curative; (NOTE: for patients with lymphoma, a re-biopsy is necessary unless the patient has had a previous biopsy < 6 months prior to treatment on this protocol if there has been no intervening treatment; patients with biopsy-proven central nervous system [CNS] lymphoma at any time are not required to have a re-biopsy to be eligible for this study)
- •Multiple myeloma:
- •Serum monoclonal protein >= 1.0 g/dL
- •>= 200 mg of monoclonal protein in the urine on 24 hour electrophoresis
- •Serum immunoglobulin free light chain >= 10 mg/dL AND abnormal serum immunoglobulin kappa to lambda free light chain ratio
- •Monoclonal bone marrow plasmacytosis >= 30% (evaluable disease) at time of registration
- •Lymphoma:
- •Measurable disease by computed tomography (CT) or magnetic resonance imaging (MRI) or the CT portion of the positron emission tomography (PET)/CT; must have at least one lesion that has a single diameter of >= 2 cm or tumor cells in the blood >= 5 x 10^9/L; skin lesions can be used if the area is >= 2 cm in at least one diameter and photographed with a ruler
- •The following disease types are eligible:
- •Transformed lymphomas
- •Diffuse large B cell lymphoma
- •Mantle cell lymphoma
- •Follicular lymphoma grade III
- •Precursor B lymphoblastic leukemia/lymphoma
- •Mediastinal (thymic) large B-cell lymphoma
- •Burkitt lymphoma/leukemia
- •Precursor T-lymphoblastic leukemia/lymphoma
- •Primary cutaneous anaplastic large cell lymphoma
- •Anaplastic large cell lymphoma - primary systemic type
- •Small lymphocytic lymphoma/chronic lymphocytic leukemia
- •Follicular lymphoma, grades 1, 2
- •Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type
- •Nodal marginal zone B-cell lymphoma
- •Splenic marginal zone B-cell lymphoma
- •Peripheral T cell lymphoma, unspecified.
- •Anaplastic large cell lymphoma (T and null cell type)
- •Lymphoplasmacytic lymphoma (Waldenstrom Macroglobulinemia)
- •CNS lymphoma
- •Post transplant lymphoproliferative disorders
- •Mycosis fungoides/Sezary syndrome
- •Hodgkin Disease
- •Primary effusion lymphoma
- •Blastic natural killer (NK)-cell lymphoma
- •Adult T-cell leukemia/lymphoma
- •Extranodal NK/T-cell lymphoma, nasal type
- •Enteropathy-type T-cell lymphoma
- •Hepatosplenic T-cell lymphoma
- •Subcutaneous panniculitis-like T-cell lymphoma
- •Angioimmunoblastic T-cell lymphoma
- •Anaplastic large cell lymphoma - primary cutaneous type
- •For lymphoplasmacytic lymphoma patients without measurable lymphadenopathy, measurable disease can be defined by both of the following criteria:
- •Bone marrow lymphoplasmacytosis with > 10% lymphoplasmacytic cells or aggregates, sheets, lymphocytes, plasma cells, or lymphoplasmacytic cells on bone marrow biopsy and
- •Quantitative immunoglobulin (Ig)M monoclonal protein > 1,000 mg/dL
- •Absolute neutrophil count (ANC) >= 1000/uL
- •Hemoglobin (Hgb) >= 9 g/dl
- •Platelets (PLT) >= 75,000/uL
- •Total bilirubin =< 1.5 x upper limit of normal (ULN) or if total bilirubin is > 1.5 x ULN the direct bilirubin must be normal
- •Aspartate aminotransferase (AST) =< 3 x ULN
- •Creatinine =< 2.5 x ULN
- 另有 9 项未显示
排除标准
- •Candidate for known standard therapy for the patient's disease that is potentially curative
- •Uncontrolled infection
- •Therapy with myelosuppressive chemotherapy or biologic therapy < 3 weeks unless the patient has recovered from the nadir of the previous treatment to a level that meets the inclusion eligibility criteria of this protocol; NOTE: patients who have received prior RAD001 therapy will be allowed but must meet above requirements
- •Receiving corticosteroids > 20 mg of prednisone per day (or equivalent); NOTE: patients may be receiving stable (not increased within the last month) chronic doses of corticosteroids with a maximum dose of 20 mg of prednisone per day if they are being given for disorders other than lymphoma (with the exception of CNS lymphoma, which steroids are permitted at the lowest possible dose necessary and should not be escalated during treatment) such as rheumatoid arthritis, polymyalgia rheumatica or adrenal insufficiency, or asthma
- •Persistent toxicities >= grade 2 from prior chemotherapy or biological therapy regardless of interval since last treatment
- •Impaired cardiac function or clinically significant cardiac diseases, including any one of the following:
- •Patients with congenital long QT syndrome
- •History or presence of sustained ventricular tachyarrhythmia; (patients with a history of atrial arrhythmia are eligible but should be discussed with the Sponsor prior to enrollment)
- •Any history of ventricular fibrillation or torsade de pointes
- •Bradycardia defined as heart rate (HR) < 50 beats per minute (bpm;) patients with pacemakers are eligible if HR >= 50 bpm
- •Screening electrocardiogram (ECG) with a QTcFredericia (QTcF) > 450 msec
- •Right bundle branch block + left anterior hemiblock (bifascicular block)
- •Patients with myocardial infarction or unstable angina =< 6 months prior to starting study drug
- •Other clinically significant heart disease (e.g., congestive heart failure [CHF] New York [NY] Heart Association class III or IV, uncontrolled hypertension, history of labile hypertension, or history of poor compliance with an antihypertensive regimen)
- •Any of the following:
- •Pregnant women or women of reproductive ability who are unwilling to use effective contraception
- •Nursing women
- •Men who are unwilling to use a condom (even if they have undergone a prior vasectomy) while having intercourse with any woman, while taking the drug and for 4 weeks after stopping treatment
- •Other concurrent chemotherapy, immunotherapy, radiotherapy, or any ancillary therapy considered investigational (utilized for a non-Food and Drug Administration [FDA]-approved indication and in the context of a research investigation); NOTE: patients may undergo palliative concurrent radiation of myeloma lesions for pain control or impending fracture, provided the lesion(s) by themselves do not constitute progression
- •Known positivity for human immunodeficiency virus (HIV) or hepatitis C with uncontrolled disease; baseline testing for HIV is not required; Note: a detailed assessment of Hepatitis B/C medical history and risk factors must be done at screening for all patients; hepatitis b virus (HBV) deoxyribonucleic acid (DNA) and hepatitis C virus (HCV) ribonucleic acid (RNA) polymerase chain reaction (PCR) testing are required at screening for all patients with a positive medical history based on risk factors and/or confirmation of prior HBV infection
- •Active other malignancy requiring treatment that would interfere with the assessments of response of the lymphoma or myeloma to protocol treatment
- •Inability to swallow or impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of the drugs (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection) that would preclude use of oral medications
- •Thrombotic or embolic events such as a cerebrovascular accident including transient ischemic attacks within the past 6 months
- •Any severe and/or uncontrolled medical conditions or other conditions that, in the treating physician's opinion, could adversely impact their ability to participate in the study; NOTE: patients on chronic oxygen therapy, those with liver disease such as cirrhosis, chronic hepatitis or chronic persistent hepatitis, or uncontrolled infections will be excluded
- •Known hypersensitivity to RAD001 (everolimus) or other rapamycins (sirolimus, temsirolimus)
- •Receiving any medications or substances that are strong or moderate inhibitors of CYP3A4; receiving any medications or substances that are inducers of CYP3A4
- •Using medications that have a relative risk of prolonging the QT interval or inducing torsade de pointes if treatment cannot be discontinued or switched to a different medication prior to starting study drug
- •Active bleeding tendency; NOTE: patients on therapeutic anticoagulation should be monitored carefully to maintain therapeutic level of anticoagulation to avoid increased risk of bleeding due to concurrent drug induced thrombocytopenia; it is suggested that patients who require anticoagulation therapy while on therapy use low molecular weight heparin (LMWH)
- •Major surgery =< 4 weeks prior to registration or have not recovered from side effects of such therapy
研究组 & 干预措施
Treatment (panobinostat and everolimus)
Patients receive panobinostat PO QD or on days 1, 3, 5, 15, 17, and 19 and everolimus PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
干预措施: panobinostat (Drug)
Treatment (panobinostat and everolimus)
Patients receive panobinostat PO QD or on days 1, 3, 5, 15, 17, and 19 and everolimus PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
干预措施: everolimus (Drug)
Treatment (panobinostat and everolimus)
Patients receive panobinostat PO QD or on days 1, 3, 5, 15, 17, and 19 and everolimus PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
干预措施: laboratory biomarker analysis (Other)
Treatment (panobinostat and everolimus)
Patients receive panobinostat PO QD or on days 1, 3, 5, 15, 17, and 19 and everolimus PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
干预措施: pharmacological study (Other)
结局指标
主要结局
Number of Phase I Participants With Dose-Limiting Toxicity Events (Phase I)
时间窗: 4 weeks
The Maximum Tolerated Dose (MTD) is defined as the dose level below the lowest dose that induces dose-limiting toxicity (DLT) in at least one-third of patients graded according to NCI Common Terminology Criteria for Adverse Events (CTCAE) version 3.0. Dose-limiting toxicities include non-hematologic events graded 3 or higher and deemed at least possibly related to treatment. A total of 6 patients treated at the MTD will be sufficient to identify common toxicities at the MTD. The number of patients reporting a dose-limiting event are reported.
Overall Response Rate (Phase II)
时间窗: Up to 12 courses
For myeloma, a complete response(CR, defined as Negative immunofixation(IFE) of the serum and urine, \< 5% plasma cells in bone marrow(BM), Disappearance of plasmacytomas), stringent CR(sCR, defined as CR plus Normal serum FLC ratio, Absence of clonal cells in BM), very good partial response(VGPR, defined as PR plus Serum and urine M-component detectable by IFE but not on electrophoresis), partial response(PR, defined as a ≥ 50% reduction of serum M-protein and/or reduction in 24-h urinary M-protein by ≥ 90% or to \<200 mg per 24 h), or minor response(MR, defined as ≥25% but \< 49% reduction of serum M-protein and reduction in 24h urine M-protein by 50-89%) noted as the objective status. For lymphoma, a CR(defined as no evidence of measurable disease), or PR(defined as regression of measurable disease and no new sites of disease) noted as the objective status. Percentage of successes will be estimated by 100 times the number of successes divided by the total number of evaluable patients.
次要结局
- Overall Survival Time (Phase II)(Time from registration to death due to any cause, assessed up to 2 years post-treatment)
- Progression-free Survival (Phase II)(Time from registration to progression or death due to any cause, assessed up to 2 years post-treatment)
- Duration of Response (Phase II)(The time from the date at which the patient's objective status is first noted to be a CR, sCR, VGPR, PR, or minor response to the earliest date progression is documented, assessed up to 2 years post-treatment)