NCT04213222Unknown不适用
A Radiomics Approach to Predict the Effect of Bevacizumab Plus Chemotherapy in Patients With Liver Metastases of Colorectal Cancer: A Prospective Multi-Centers Trial
适应症
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- estimated ORR
研究概览
简要总结
Colorectal carcinoma with liver metastasis is one of the major problems bothering physicians worldwide. Bevacizumab combined with chemotherapy is the standard treatment recommended by several guidelines. Despite the high cost, a certain portion of patients couldn't benefit from this therapy. This study is aiming to find out the specific type of patients who would respond to bevacizumab by Radiomics approach, and evaluate the prediction value of this imaging model with clinical and genetic factors.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Colorectal carcinoma confirmed by pathological result.
- •Liver metastasis confirmed by imaging studies.
- •Treatment of bevacizumab combined with chemotherapy chosen by MDT team.
- •Normal laboratory studies including liver\renal\bone marrow functions.
- •Expected lifespan more than 3 months.
排除标准
- •Previous treatment of colorectal cancer with liver metastasis.
- •Diagnosed with other malignancies.
- •Couldn't finish the trial due to several reasons such as allergy to chemotherapy drugs\pregnancy or lactation\chronic heart disease\unable to sustain further treatment.
结局指标
主要结局
estimated ORR
时间窗: 6-8 weeks
次要结局
- estimated OS(3 years)
- estimated PFS(3 years)
研究者
研究点 (1)
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