Genicular Nerve Block Versus Its Combination With Infiltration Between Popliteal Artery and Capsule of Posterior Knee

Not Applicable

Recruiting

• Conditions: Postoperative Pain
• Interventions: Drug: standard analgesia (paracetamol and meloxicam); Procedure: GNB plus standard analgesia; Procedure: GNB plus IPACK block plus standard analgesia

• Registration Number: NCT05672784
• Lead Sponsor: Zagazig University

Brief Summary

Comparison of the analgesic and physical recovery effect of genicular nerve block (GNB) alone and (GNB + infiltration between popliteal artery and posterior capsule of the knee (IPACK) in patients undergoing total knee replacement

Detailed Description

Comparison of preemptive analgesia of (GNB) with (GNB+ IPACK) on postoperative pain control and recovery of knee physical activity in patient undergoing total knee replacement.

Study Timeline

• Study Start: 2022-11-05
• Study First Submitted: 2022-11-05
• Study First Submitted QC: 2023-01-04
• Study First Posted: 2023-01-05
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-22
• Last Update Posted: 2024-11-26
• Primary Completion: 2024-12-05
• Study Completion: 2024-12-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 63

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
C group	standard analgesia (paracetamol and meloxicam)	the patients will take standard analgesia ( meloxicam (15 mg) once a day + paracetamol 1gm /3 times a day). ,with no nerve block
G group	GNB plus standard analgesia	the patients will take standard analgesia plus GNB
G group	standard analgesia (paracetamol and meloxicam)	the patients will take standard analgesia plus GNB
GI group	GNB plus IPACK block plus standard analgesia	the patients will take standard analgesia plus GNB plus IPACK
GI group	standard analgesia (paracetamol and meloxicam)	the patients will take standard analgesia plus GNB plus IPACK

Primary Outcome Measures

Name	Time	Method
2 hours visual analogue scale	at 2 hour postoperative.	pain intensity at rest and with motion using visual analogue scale from " horizontal line of 10-cm long with two ends, one end indicate no pain 0 and the other end indicate worst pain 10".
4 hours visual analogue score	at 4 hours postoperative	pain intensity at rest and with motion using visual analogue scale from " horizontal line of 10-cm long with two ends, one end indicate no pain 0 and the other end indicate worst pain 10".
8 hours visual analogue score	at 8 hours postopertaive	pain intensity at rest and with motion using visual analogue scale from " horizontal line of 10-cm long with two ends, one end indicate no pain 0 and the other end indicate worst pain 10".
18 hours visual analogue score	at 18 hours postoperative	pain intensity at rest and with motion using visual analogue scale from " horizontal line of 10-cm long with two ends, one end indicate no pain 0 and the other end indicate worst pain 10".
24 hours visual analogue score	at 24 hours postoperative	pain intensity at rest and with motion using visual analogue scale from " horizontal line of 10-cm long with two ends, one end indicate no pain 0 and the other end indicate worst pain 10".
6 hours visual analogue score	at 6 hours postoperative	pain intensity at rest and with motion using visual analogue scale from " horizontal line of 10-cm long with two ends, one end indicate no pain 0 and the other end indicate worst pain 10".
12 hours visual analogue score	at 12 hours postoperative	pain intensity at rest and with motion using visual analogue scale from " horizontal line of 10-cm long with two ends, one end indicate no pain 0 and the other end indicate worst pain 10".

Secondary Outcome Measures

Name	Time	Method
• Total morphine consumption	at 24 hours post-operatively	Total morphine consumption
degree of maximum active flexion and extension of the knee	at 24 hours post operative	the angle of maximum active flexion and extension of the knee
walk test	at 24 hours post operative	walking distance in meters that patients can wake during 2 min
holding quadriceps muscle	at 24 hours post operative	number of patients capable to hold quadriceps muscle more than 5 seconds.
• Time of performance of block	from putting of U.S probe till the end of block procedure	defined as time from putting of U.S probe till the end of block procedure.
•incidence of Anticipated side effect	at 24,48 hours postoperative	nausea, vomiting, itching, hemorrhage, bradycardia and hypotension.
time up and go (TUG)	at 24 hours post operative	the time required for the patient to stand up from a standard-height armchair, walk 3 meters, turn, walk back to the chair, and sit down

Trial Locations

Locations (1)

Heba M Fathi; 🇪🇬 Zagazig, Egypt