Observational, Non-interventional, Multicenter Study Aimed at Collecting Retrospective/Prospective 648/96 Italian Registry Data Related to Lenalidomide (Revlimid®) Prescription to Patients With Myelodysplastic Syndromes
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Myelodysplastic Syndrome
- Sponsor
- Celgene
- Enrollment
- 149
- Locations
- 45
- Primary Endpoint
- Number of subjects achieving red blood cell (RBC) transfusion independence
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The purpose of this study is to collect clinical and laboratory data for patients affected by intermediate 1 and low risk Myelodysplastic Syndrome (MDS) associated by deletion 5q who were prescribed Revlimid from 31October 2008 to present. Revlimid is available in Italy for these patients since October 2008 based on a local disposition of the Italian Drug Agency (AIFA) issued according to a National law named 648/96.
Detailed Description
There will be retrospective collection and integration of clinical laboratory data as well as prospective data collection on the same patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •intermediate 1 and low risk MDS patients associated with:
- •transfusion dependency anemia (at least 2 units per 8 weeks before starting of Revlimid treatment )
- •5q31-33 deletion isolated or associated to other chromosomal abnormalities.
Exclusion Criteria
- •patients with serum creatinine \> 2.5mg/dl
- •child bearing potential females who do not use adequate contraceptive methods
Outcomes
Primary Outcomes
Number of subjects achieving red blood cell (RBC) transfusion independence
Time Frame: 14 months
Number of subjects achieving an erythroid response
Time Frame: 14 months
Number of subjects achieving a cytogenetic response
Time Frame: 14 months
Secondary Outcomes
- Number of participants with adverse events(14 months)
- Time to RBC transfusion independence(14 months)
- Duration of RBC transfusion independence(14 months)
- Number of participants alive(14 months)
- Duration of cytogenetic response(14 months)
- Progression to acute myeloid leukemia (AML)(14 months)