NL-OMON42474
Completed
Not Applicable
The role of the dopamine and opioid systems in pain-avoidance learning - dopamine, opioids and pain-avoidance learning
niversiteit Leiden0 sites91 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- scientific investigation of healthy subjects
- Sponsor
- niversiteit Leiden
- Enrollment
- 91
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Trial is onging in other countries
Investigators
Eligibility Criteria
Inclusion Criteria
- •Healthy adult subjects with no history of neurological disorder/disease or chronic pain, and no counter\-indications to 3 Tesla MRI or to levodopa or naltrexone, and no personal relationship with the researchers will be included in this study. All participants will be right\-handed native\-Dutch speakers with normal vision or contact lenses.
Exclusion Criteria
- •Potential participants will be prescreened for contra\-indications for 3 Tesla fMRI and levodopa/naltrexone, which include metal implants, heart arrhythmia, claustrophobia, glaucoma, hypertension and use of anti\-depressants or psychotropic medication and possible pregnancy (in adult females). They will additionally be prescreened for head trauma, premature birth, learning disabilities, chronic pain, and history of neurological or psychiatric illness. Finally, left\-handed
- •individuals will be excluded from the study because some left\-handers have substantially different brain organization relative to right\-handers.
Outcomes
Primary Outcomes
Not specified
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