The impact of norepinephrine on the dynamic aspect of brain activity

Completed

Conditions: scientific investigation of healthy subjects
healthy

Registration Number: NL-OMON49449

Lead Sponsor: niversiteit Leiden

Brief Summary: Trial is onging in other countries

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 36

Inclusion Criteria

Healthy adult subjects with no history of neurological disorder/disease and no
counter-indications to 3 Tesla MRI or to atomoxetine, and no personal
relationship with the researchers will be included in this study. All
participants will be right-handed with normal vision or contact lenses.

Exclusion Criteria

Significant history of head trauma, premature birth, learning disabilities,
neurological or psychiatric illness. Heart arrhythmia, glaucoma, congenital eye
diseases, hyperopia, myopia, hypertension and use of anti-depressants or
psychotropic medication and possible pregnancy (in adult females). MRI
contra-indications, including metal implants and claustrophobia. Smoking more
than five cigarettes a day - to avoid nicotine withdrawal effects during the
study. Alcohol consumption < 24 hours before study, caffeine consumption < 3
hours before study.
These criteria will be assessed by a self-report questionnaire administered
during pre-screening.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>* Behavioural measures: effect of atomoxetine on accuracy and reaction time.<br /><br>* Brain activity measures: effect of atomoxetine on task-related evoked BOLD<br /><br>signal, measures of information flow, and correlation measures between BOLD<br /><br>time courses in regions of interest.<br /><br>* Computational measures: model fit to empirical fMRI data under different<br /><br>levels of atomoxetine.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* Psychometric measures: state anxiety, trait anxiety, emotional arousal, as<br /><br>regressors for behavioural and fMRI data.<br /><br>* Psychophysiological measures: task-related and task-unrelated changes in<br /><br>pupil size, as regressors for behavioural and fMRI data..<br /><br>* Physiological measures: salivary cortisol and alpha amylase, as regressor for<br /><br>behavioural and fMRI data.</p><br>