Comparison of Healing with Different Sutures After Wisdom Tooth Removal

Not yet recruiting

Conditions: patients with ASA I and II requiring intraoral incisions and impacted third molar extraction

Registration Number: CTRI/2025/06/088528

Brief Summary: Mandibular third molar extraction is a common oral surgical procedure frequently associated with postoperative complications such as pain, edema, trismus, hematoma, prolonged bleeding, pyrexia, and alveolar osteitis. These adverse effects can delay recovery and increase the risk of secondary infections and chronic pain. Sutures are critical in promoting wound stability and healing. This single-blinded, randomized controlled clinical trial aims to evaluate the efficacy of 1.5% hyaluronic acid (HA)-impregnated 3-0 mersilk sutures compared to conventional 3-0 mersilk and 3-0 Vicryl Plus sutures in mandibular third molar surgery. A total of 84 extraction sites will be randomly allocated into three equal groups (n=28): HA-impregnated mersilk (Group I), vicryl Plus (Group II), and conventional mersilk (Group III). Randomization will be conducted via coin flip, and outcome assessment will be blinded. Clinical wound healing will be evaluated using Landry’s Healing Index on postoperative days 1, 3, and 7. Microbial colonization will be assessed by colony-forming unit (CFU) counts, and pain levels will be measured using the Visual Analog Scale (VAS).The study hypothesizes that HA-impregnated mersilk sutures will demonstrate superior outcomes in wound healing, microbial control, and pain reduction. HA’s anti-inflammatory and antimicrobial properties may enhance tissue regeneration and minimize postoperative complications, potentially improving patient recovery and overall clinical outcomes.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 78

Inclusion Criteria

Participants within the age group of 18 to 50 years.
Patients requiring surgical removal of mandibular third molars.
Willingness to comply with the postoperative care instructions and follow-up visits.

Exclusion Criteria

• Current use of medications known to affect wound healing, including corticosteroids or immunosuppressants.
• Patients not willing to participate in the study.
• Medically compromised like having diabetes, hypertension, pregnant females and anxious patients.
• Patients with a history of allergy to anesthetics or acute inflammation at the surgical site.
• Patients with existing oral infections or pericoronitis.
• Known allergy to local anesthetics or suture materials.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
A. Clinical Parameters	Post- operative day 1st, 3rd and 7th.
-Visual Analog Scale for pain and discomfort	Post- operative day 1st, 3rd and 7th.
-Landry’s Healing Index (3rd and 7th day)	Post- operative day 1st, 3rd and 7th.
-Clinician-rated suture handling and removal	Post- operative day 1st, 3rd and 7th.
Total CFU count on blood agar, chocolate agar, MacConkey agar	Post- operative day 1st, 3rd and 7th.
Bacterial species identification (e.g., Streptococcus, Lactobacillus)	Post- operative day 1st, 3rd and 7th.
B. Microbiological Parameters	Post- operative day 1st, 3rd and 7th.

Secondary Outcome Measures

Name	Time	Method

Trial Locations

Locations (1): Santosh Dental College and Hospital, Ghaziabad, Uttar Pradesh
🇮🇳
Ghaziabad, UTTAR PRADESH, India
Santosh Dental College and Hospital, Ghaziabad, Uttar Pradesh
🇮🇳Ghaziabad, UTTAR PRADESH, India
Dr Shraddha Sonwane
Principal investigator
9869134018
shraddhasonwane511@gmail.com