Prospective "Pre-post" Pilot Study on the Effects of Dietary Chloride Supplementation on Neurohormonal and Diuretic Function in Patients With Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- Change in plasma renin activity following lysine chloride administration
研究概览
简要总结
The purpose of this study is to determine if administration of supplemental chloride in the form of lysine chloride to patients with congestive heart failure will affect their neurohormonal profile as well as response to diuretics.
详细描述
This prospective pilot "pre-post" study was designed to determine if supplementation of sodium free chloride ion as a lysine chloride to patients with heart failure could improve parameters of neurohormonal status and diuretic responsiveness. Volunteers will receive Lysine Chloride 7 grams three times daily for three days. At baseline and then again post lysine chloride patients will undergo sampling of venous blood for determination of neurohormonal parameters in addition to formal diuretic responsiveness testing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years
- •Fluency in English
- •Heart failure requiring loop diuretic therapy
- •Loop diuretic dose ≥ 80mg/day furosemide equivalents
- •Stable volume status and diuretic requirement as assessed by treating physician
排除标准
- •Unstable heart failure
- •renal replacement therapy or an estimated GFR < 30 ml/min/1.73m2
- •Significant bladder dysfunction
- •History of hepatic failure
- •Pregnancy
- •History of hyperinsulinemia/hyperlysinuria
研究组 & 干预措施
Lysine Chloride
干预措施: Lysine Chloride (Dietary Supplement)
结局指标
主要结局
Change in plasma renin activity following lysine chloride administration
时间窗: 3 days
Change in diuretic response following lysine chloride administration
时间窗: 3 days
Diuretic response will me evaluated by measuring volume of urine produced following diuretic administration
Change in urinary renin level following lysine chloride administration
时间窗: 3 days
次要结局
未报告次要终点