Effects of Hookah Smoking on Blood Flow to the Heart, Muscle and Skin
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Cedars-Sinai Medical Center
- Enrollment
- 42
- Locations
- 1
- Primary Endpoint
- Sympathetic nerve activity
Study Overview
Brief Summary
This is a pilot study on acute effects of Hookah smoking on the sympathetic neural control of the human cardiovascular system. Hookah smoking is known to transiently increase blood pressure and heart rate while decreasing heart rate variability suggesting - but not proving - sympathetic mediation. Here the investigators will directly measure the acute effects of Hookah smoking on sympathetic nerve activity with microneurography (intraneural microelectrodes) and quantify associated regional changes in vasomotor tone.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 39 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •18 to 39 years of age
- •Habitual Hookah smoker defined as having smoked Hookah >=12 times in the past 12 months
- •Have not smoked cigarettes within the past 12 months
Exclusion Criteria
- •Exhaled carbon monoxide level greater than 10 ppm* as evidence of current or recent cigarette (excluded if smoked cigarette within 12 months) or Hookah smoking (excluded if smoked Hookah within past 72 hours)
- •History of cardiopulmonary disease
- •Use of any prescription medication with exception of oral contraceptive pills
- •History of psychiatric illness
- •History of neurologic disease
- •Evidence of any of the above by physical examination, ECG or echocardiogram
- •Smoked cigarette in the past 12 months
- •History of illicit drug use
- •Any other condition(s) deemed by the physician investigators that put subjects at risk for participating in the study
Arms & Interventions
Hookah smoking
Healthy habitual Hookah smokers will undergo microneurography, myocardial contrast echocardiogram or venous occlusion plethysmography before and after Hookah smoking.
Intervention: Hookah smoking (Other)
Outcomes
Primary Outcomes
Sympathetic nerve activity
Time Frame: At the initial study visit
Multi-unit recordings of sympathetic nerve activity will be obtained with single-use sterile tungsten microelectrodes inserted selectively into muscle or skin nerve fascicles of the peritoneal nerve.
Secondary Outcomes
- Myocardial contrast echocardiography(At the initial study visit)