Effects of Hookah Smoking on Vascular Regulation: Novel Insight Into Endothelial Function
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Cedars-Sinai Medical Center
- Enrollment
- 58
- Locations
- 1
- Primary Endpoint
- Brachial artery flow-mediated dilation
Study Overview
Brief Summary
The purpose of this study is to assess the acute effects of Hookah (waterpipe) smoking on blood vessel function. Hookah smoking has been shown to immediately increase blood pressure and heart rate which could result in damage in the inner lining of the body's blood vessels.
Detailed Description
The investigators will measure acute endothelial and vascular changes before and after a 30-minute Hookah smoking session in a controlled laboratory environment to: (1) Determine the acute effects of Hookah smoking on large-vessel endothelial vasodilator function measured by brachial artery flow mediated dilation; (2) Determine the acute effects of Hookah smoking on micro-vessel endothelial function as measured by reactive hyperemia peripheral arterial tonometry; (3) Determine the acute effects of Hookah smoking on pulse wave velocity and aortic pressure waveform measured by pulse tonometry.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 29 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •18 to 29 years of age
- •Habitual Hookah smoker defined as having smoked Hookah >=12 times in the past 12 months
- •Have not smoked cigarettes within the past 12 months
Exclusion Criteria
- •History of cardiopulmonary, diabetes, dyslipidemia or psychiatric disease
- •Exhaled carbon monoxide level >10 ppm
- •BP < 140/90 mmHg
- •BMI <18.5 or > 30 kg•m2
- •Resting heart rate > 100 beats/min
- •Taking prescription medication
- •History of illicit drug use
Arms & Interventions
Hookah smoking
Healthy habitual Hookah smokers will undergo brachial artery flow mediated dilation, reactive hyperemia peripheral arterial tonometry or pulse tonometry before and after Hookah smoking.
Intervention: Hookah smoking (Other)
Outcomes
Primary Outcomes
Brachial artery flow-mediated dilation
Time Frame: change from baseline to immediately after smoking
Secondary Outcomes
- Reactive hyperemia peripheral arterial tonometry(change from baseline to immediately after smoking)
Investigators
Florian Rader
M.D, M.Sc.
Cedars-Sinai Medical Center