NCT05454267招募中不适用
Early Detection of Vaping-related Vascular Diseases
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- Airway blood flow reactivity (QAW)
研究概览
简要总结
The purpose of this study is to determine how vaping affects blood vessels, in particular if early damage occurs in the lung vessels.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Vapers Group:
- •Current electronic cigarette (EC) Puff Bar users defined as using EC either daily or occasionally in the past 30 days for at least 6 months, and with 5% nicotine concentration pods.
- •Adults aged 18-40 years
- •Healthy Group:
- •Healthy never smokers, never vapers
- •Adults aged 18-40 years
排除标准
- •Current or past smoking of tobacco cigarette (TC) or other tobacco/nicotine products (e.g., smokeless tobacco, Hookah) or marijuana will be excluded from the study.
- •Subjects with self-reported history of chronic health problems including asthma, chronic obstructive pulmonary disease (COPD), morbid obesity (BMI>40 kg/m2), hypertension or diabetes
- •Pregnant or breastfeeding women
研究组 & 干预措施
Healthy Volunteer Group
Participants who have never smoked or vaped
High Frequency Vaping Group
Participants who vape >20 days per month.
Low-Frequency Vaping Group
Participants who vape < 20 days per month
结局指标
主要结局
Airway blood flow reactivity (QAW)
时间窗: Up to 1 week
QAW will be measured via soluble gas uptake method
Pulmonary vascular resistance (PVR)
时间窗: Up to 4 weeks
PVR will be measured via echocardiography
Flow-mediated vasodilation (FMD)
时间窗: Up to 4 weeks
FMD will be measured by blood pressure cuff deflation using ultrasound
次要结局
未报告次要终点
研究者
Adam Wanner
Professor of Medicine
University of Miami
研究点 (2)
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